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1. (WO2013113252) METHOD FOR REGULATING EXPRESSION LEVEL OF CYP GENE AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/113252 International Application No.: PCT/CN2013/000091
Publication Date: 08.08.2013 International Filing Date: 30.01.2013
IPC:
C12N 15/113 (2010.01) ,C12N 15/85 (2006.01) ,C12N 15/86 (2006.01) ,C12N 15/861 (2006.01) ,C12N 15/867 (2006.01) ,C12N 15/869 (2006.01) ,C12N 15/12 (2006.01)
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Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
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Recombinant DNA-technology
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Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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Vectors or expression systems specially adapted for eukaryotic hosts
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Recombinant DNA-technology
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Genes encoding animal proteins
Applicants: PEKING UNIVERSITY[CN/CN]; No. 5, Yiheyuan Road, Haidian District Beijing 100871, CN
Inventors: DU, Quan; CN
Agent: CHINA PATENT AGENT (H.K.) LTD.; 22/F, Great Eagle Centre, 23 Harbour Road Wanchai, Hong Kong, CN
Priority Data:
201210023123.802.02.2012CN
201310015230.016.01.2013CN
Title (EN) METHOD FOR REGULATING EXPRESSION LEVEL OF CYP GENE AND USE THEREOF
(FR) PROCÉDÉ DE RÉGULATION DU NIVEAU D'EXPRESSION DU GÈNE CPY ET UTILISATION DE CELUI-CI
(ZH) 一种调控CYP基因表达水平的方法及其应用
Abstract:
(EN) Provided are a method for regulating expression level of non-human mammalian cytochrome P450 (CPY) gene and uses thereof in producing non-human mammalian model. Furthermore, also provided are animal models produced by using the method and uses of the animal model in preclinical study of drugs.
(FR) La présente invention se rapporte à un procédé de régulation du niveau d'expression du gène du cytochrome P450 (CPY) de mammifère non humain et à son utilisation dans la production d'un modèle mammifère non humain. L'invention porte également sur des modèles animaux produits au moyen de ce procédé et sur des applications de ces modèles animaux dans l'étude préclinique de médicaments.
(ZH) 提供了一种调控非人类哺乳动物细胞色素P450 (CYP)基因表达水平的方法以及该方法在产生非人类哺乳动物模型中的应用;进一步地,还提供了利用该方法产生的动物模型,以及该动物模型在临床前药物研究中的应用。
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)