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1. (WO2013113074) COMBINATION THERAPY COMPRISING A GROWTH HORMONE VARIANT AND AN OLIGONUCLEOTIDE TARGETED TO THE GROWTH HORMONE RECEPTOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/113074    International Application No.:    PCT/AU2013/000095
Publication Date: 08.08.2013 International Filing Date: 04.02.2013
IPC:
A61P 5/08 (2006.01), A61K 31/7088 (2006.01), A61K 38/27 (2006.01)
Applicants: ANTISENSE THERAPEUTICS LTD [AU/AU]; 6 Wallace Avenue Toorak, Victoria 3142 (AU)
Inventors: TACHAS, George; (AU)
Agent: FB RICE; Level 23 200 Queen Street Melbourne, Victoria 3000 (AU)
Priority Data:
61/594,532 03.02.2012 US
Title (EN) COMBINATION THERAPY COMPRISING A GROWTH HORMONE VARIANT AND AN OLIGONUCLEOTIDE TARGETED TO THE GROWTH HORMONE RECEPTOR
(FR) POLYTHÉRAPIE COMPRENANT UN VARIANT DE L'HORMONE DE CROISSANCE ET UN OLIGONUCLÉOTIDE CIBLANT LE RÉCEPTEUR DE L'HORMONE DE CROISSANCE
Abstract: front page image
(EN)The present disclosure relates to a method for treatment or prevention of diseases have an increased level of insulin-like growth factor I (IGF-I). The method comprises administration of a growth hormone (GH) variant having antagonistic activity in combination with an oligonucleotide targeted to growth hormone receptor (GHR) to a subject in need.
(FR)La présente invention concerne une méthode de traitement ou de prévention de maladies présentant un taux élevé de facteur de croissance 1 analogue à l'insuline (IGF-1). La méthode comprend l'administration d'un variant de l'hormone de croissance (GH) présentant une activité antagoniste en association avec un oligonucléotide ciblant le récepteur de l'hormone de croissance (GHR) à un patient ayant besoin d'un tel traitement.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)