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1. (WO2013112999) METHODS AND ARRAYS FOR CONTROLLED MANIPULATION OF DNA AND CHROMATIN FRAGMENTS FOR GENETIC AND EPIGENETIC ANALYSIS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/112999 International Application No.: PCT/US2013/023450
Publication Date: 01.08.2013 International Filing Date: 28.01.2013
IPC:
C12Q 1/68 (2006.01) ,G01N 33/48 (2006.01) ,G01N 21/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21
Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible, or ultra-violet light
Applicants:
CERF, Aline [FR/FR]; FR
CRAIGHEAD, Harold, G. [US/US]; US
TIAN, Harvey, C. [US/US]; US
CORNELL UNIVERSITY [US/US]; CCTEC 395 Pine Tree Road, Suite 310 Ithaca, NY 14850, US
Inventors:
CERF, Aline; FR
CRAIGHEAD, Harold, G.; US
TIAN, Harvey, C.; US
Agent:
GONSALVES, Andrew, K.; Heslin Rothenberg Farley & Mesiti P.C. 5 Columbia Circle Albany, NY 12203, US
Priority Data:
61/591,60627.01.2012US
61/667,49103.07.2012US
Title (EN) METHODS AND ARRAYS FOR CONTROLLED MANIPULATION OF DNA AND CHROMATIN FRAGMENTS FOR GENETIC AND EPIGENETIC ANALYSIS
(FR) PROCÉDÉS ET RÉSEAUX POUR LA MANIPULATION RÉGULÉE DE FRAGMENTS D'ADN ET DE CHROMATINE POUR DES ANALYSES GÉNÉTIQUES ET ÉPIGÉNÉTIQUES
Abstract:
(EN) The present invention relates to methods and arrays for use in high resolution imaging of individual nucleic acid molecules and chromatin fragments, including native chromatin fragments. In one aspect, the present invention relates to a chromatin array that includes a transfer platform having a support and a transfer surface layered on the support. The chromatin array also includes a plurality of elongated individual native chromatin fragments coupled to the transfer surface in an orderly pattern suitable for high resolution imaging of the plurality of native chromatin fragments. The native chromatin fragments of the chromatin array include both DNA and histones.
(FR) La présente invention concerne des procédés et des réseaux destinés à être utilisés dans l'imagerie à grande résolution de molécules d'acide nucléique individuelles et de fragments de chromatine, y compris de fragments de chromatine native. Dans un aspect, la présente invention concerne un réseau de chromatine qui comprend une plateforme de transfert ayant un support et une surface de transfert stratifiée sur le support. Le réseau de chromatine comprend également une pluralité de fragments de chromatine native individuels et allongés, couplés à la surface de transfert selon un motif ordonné adapté à l'imagerie haute résolution de la pluralité de fragments de chromatine native. Les fragments de chromatine native sur le réseau de chromatine comprennent à la fois l'ADN et les histones.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)