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1. (WO2013112804) FORMULATIONS OF 3-(6-(1-(2.2-DIFLUOROBENZO[D][1,3]DIOXOL-5-YL) CYCLOPROPANECARBOXAMIDO)-3-METHYLPYRIDIN-2-YL)BENZOIC ACID

Pub. No.:    WO/2013/112804    International Application No.:    PCT/US2013/023100
Publication Date: Fri Aug 02 01:59:59 CEST 2013 International Filing Date: Sat Jan 26 00:59:59 CET 2013
IPC: A61K 9/16
A61K 9/20
A61K 9/28
C07D 213/75
C07D 405/12
C07D 405/14
A61K 31/443
Applicants: VERTEX PHARMACEUTICALS INCORPORATED
VERWIJIS, Marinus, Jacobus
Inventors: VERWIJIS, Marinus, Jacobus
Title: FORMULATIONS OF 3-(6-(1-(2.2-DIFLUOROBENZO[D][1,3]DIOXOL-5-YL) CYCLOPROPANECARBOXAMIDO)-3-METHYLPYRIDIN-2-YL)BENZOIC ACID
Abstract:
A pharmaceutical composition comprising Compound 1, (3-(6-(l-(2,2- difluorobenzo [d] [ 1,3 ] dioxol-5 -yl) cyclopropanecarboxamido)-3 -methylpyridin-2-yl)benzoic acid), and at least one excipient selected from: a filler, a disintegrant, a surfactant, a binder, and a lubricant, the composition being suitable for oral administration to a patient in need thereof to treat a CFTR mediated disease such as Cystic Fibrosis. Processes of preparing pharmaceutical compositions comprising Compound 1 are also disclosed.