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1. (WO2013112765) EFFECT OF ORALLY ADMINISTERED DIPTERINYL CALCIUM PENTAHYDRATE (DCP) ON ORAL GLUCOSE TOLERANCE IN DIO MICE

Pub. No.:    WO/2013/112765    International Application No.:    PCT/US2013/023027
Publication Date: Fri Aug 02 01:59:59 CEST 2013 International Filing Date: Fri Jan 25 00:59:59 CET 2013
IPC: A61P 3/10
Applicants: SANRX PHARMACEUTICALS, INC.
Inventors: MOHENO, Phillip
FUCHS, Dietmar
NIKOULINA, Svetlana, E.
Title: EFFECT OF ORALLY ADMINISTERED DIPTERINYL CALCIUM PENTAHYDRATE (DCP) ON ORAL GLUCOSE TOLERANCE IN DIO MICE
Abstract:
Provided herein are methods of treating diabetes comprising administering to a subject a therapeutically effective amount of dipterinyl calcium pentahydrate (DCP). Dipterinyl calcium pentahydrate (DCP) is a molecular entity whose structure is based upon the endogenous substance pterin, has effects on glucose tolerance and other measures in vivo were determined in mice fed a high-fat diet to induce obesity and insulin resistance. DCP was found to significantly improve oral glucose tolerance (OGTT) in female DIO mice,C57BL/67.