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1. (WO2013112706) PROTEASOME ACTIVITY MODULATING COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/112706    International Application No.:    PCT/US2013/022921
Publication Date: 01.08.2013 International Filing Date: 24.01.2013
IPC:
A61K 31/519 (2006.01)
Applicants: PROTEOSTASIS THERAPEUTICS, INC. [US/US]; 200 Technology Square, Suite 402 Cambridge, MA 02139 (US)
Inventors: CHAMBERS, Robert, J.; (US).
FOLEY, Megan; (US).
TAIT, Bradley; (US)
Agent: HODA, Mahreen, Chaudhry; Elmore Patent Law Group 484 Groton Road Westford, MA 01886 (US)
Priority Data:
61/739,069 19.12.2012 US
61/590,605 25.01.2012 US
61/681,410 09.08.2012 US
Title (EN) PROTEASOME ACTIVITY MODULATING COMPOUNDS
(FR) COMPOSÉS PERMETTANT DE MODULER L'ACTIVITÉ DE PROTÉASOME
Abstract: front page image
(EN)The present invention is directed to compounds that are inhibitors of the deubiquitinating enzyme, USP14, encompassed by the Formulae (I), (la) and (lb), compositions thereof, methods for the treatment of a condition associated with a dysfunction in proteostasis, methods for enhancing proteasome activity and methods for treating conditions associated with proteostasis dysfunction, such as cancer or tumor.
(FR)La présente invention porte sur des composés représentant des inhibiteurs de l'enzyme de désubiquitination, USP14, incluse par les Formules (I), (la) et (lb), des compositions associées, des procédés de traitement d'un état associé à un dysfonctionnement de la protéostasie, des procédés d'amélioration de l'activité de protéasome et des procédés de traitement d'états associés à un dysfonctionnement de la protéostasie, tel qu'un cancer ou une tumeur.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)