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1. (WO2013112699) PROTEASOME ACTIVITY ENHANCING COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/112699 International Application No.: PCT/US2013/022912
Publication Date: 01.08.2013 International Filing Date: 24.01.2013
IPC:
A61K 31/519 (2006.01)
Applicants: PROTEOSTASIS THERAPEUTICS, INC.[US/US]; 200 Technology Square, Suite 402 Cambridge, MA 02139, US
Inventors: CHAMBERS, Robert, J.; US
FOLEY, Megan; US
TAIT, Bradley; US
Agent: HODA, Mahreen, Chaudhry; Elmore Patent Law Group 484 Groton Road Westford, MA 01886, US
Priority Data:
61/590,60625.01.2012US
61/739,07719.12.2012US
Title (EN) PROTEASOME ACTIVITY ENHANCING COMPOUNDS
(FR) COMPOSÉS RENFORÇANT L'ACTIVITÉ DES PROTÉASOMES
Abstract: front page image
(EN) The present invention is directed to compounds that are inhibitors of the deubiquitinating enzyme, USP14, encompassed by the Formulae (I), (la) and (lb), compositions thereof, methods for the treatment of a condition associated with a dysfunction in proteostasis, methods for enhancing proteasome activity and methods for treating conditions associated with proteostasis dysfunction, such as cancer or tumor.
(FR) Cette invention concerne des composés de Formule (I), (Ia) ou (Ib), des compositions les contenant et des méthodes destinées à traiter une affection associée à un dysfonctionnement de la protéostasie.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)