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1. (WO2013112690) PIV5 AS ONCOLYTIC AGENT

Pub. No.:    WO/2013/112690    International Application No.:    PCT/US2013/022898
Publication Date: Fri Aug 02 01:59:59 CEST 2013 International Filing Date: Fri Jan 25 00:59:59 CET 2013
IPC: A61K 39/155
Applicants: UNIVERSTIY OF GEORGIA RESEARCH FOUNDATION, INC.
HE, Biao
Inventors: HE, Biao
Title: PIV5 AS ONCOLYTIC AGENT
Abstract:
The present invention includes the Paramyxovirus Parainfluenza Virus 5 (PIV5) as an oncolytic agent for treating various cancers, including, but not limited to breast cancer, lung cancer and melanoma. PIV5 oncolytic agents include both wild type PIV5 and various recombinant PIV5 constructs. Recombinant PIV5 constructs may include PIV5 lacking the conserved C-terminus of the V protein (PIV5VAC), PIV5 with mutations in the N-terminus of the V/P protein (PIV5CPI-), and PIV5 expressing MDA-7/IL-24 (rPIV5-MDA7), rPIV5-V/P- CPI-, rPIV5-CPI+, rPIV-Rev, rPIV5-RL, rPIV5-P-S157A, rPIV5-P-S308A, rPIV5-L-A1981D, rPIV5-F-S443P, rPIV5-MDA7, rPIV5ASH-CPI-, or rPIV5ASH-Rev. Also included are methods of making and using such oncolytic agents and compositions including such oncolytic agents.