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1. (WO2013112651) PROTEASOME ACTIVITY MODULATING COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/112651 International Application No.: PCT/US2013/022831
Publication Date: 01.08.2013 International Filing Date: 24.01.2013
IPC:
A61K 31/519 (2006.01)
Applicants: PROTEOSTASIS THERAPEUTICS, INC.[US/US]; 200 Technology Square Suite 402 Cambridge, MA 02139, US
Inventors: CHAMBERS, Robert, J.; US
FOLEY, Megan; US
TAIT, Bradley; US
Agent: HODA, Mahreen, Chaudhry; Elmore Patent Law Group 484 Groton Road Westford, MA 01886, US
Priority Data:
61/590,60525.01.2012US
61/681,41009.08.2012US
61/739,06919.12.2012US
Title (EN) PROTEASOME ACTIVITY MODULATING COMPOUNDS
(FR) COMPOSÉS MODULANT L'ACTIVITÉ DU PROTÉASOME
Abstract:
(EN) The present invention is directed to compounds that are inhibitors of the deubiquitinating enzyme, USP14, encompassed by the Formulae (I), (la) and (lb), compositions thereof, methods for the treatment of a condition associated with a dysfunction in proteostasis, methods for enhancing proteasome activity and methods for treating conditions associated with proteostasis dysfunction, such as cancer or tumor.
(FR) La présente invention concerne des composés ayant la formule (I), (la) ou (Ib), des compositions les comprenant et des procédés pour le traitement d'une pathologie associée à un dysfonctionnement de la protéostase.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)