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1. (WO2013112601) METHODS OF TREATMENT OF CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/112601    International Application No.:    PCT/US2013/022765
Publication Date: 01.08.2013 International Filing Date: 23.01.2013
IPC:
G01N 33/50 (2006.01)
Applicants: MILLENNIUM PHARMACEUTICALS, INC. [US/US]; 40 Landsdowne Street Cambridge, MA 02139 (US)
Inventors: BLAKEMORE, Stephen, J.; (US).
DI BACCO, Alessandra, M.; (US).
MULLIGAN, George, J.; (US)
Agent: GRIFFITHS, Sian, L.; Millennium Pharmaceuticals, Inc. 40 Landsdowne Street Cambridge, MA 02139 (US)
Priority Data:
61/590,131 24.01.2012 US
Title (EN) METHODS OF TREATMENT OF CANCER
(FR) MÉTHODES DE TRAITEMENT DU CANCER
Abstract: front page image
(EN)The present invention provides a method of treating cancer with a proteasome inhibitor. The invention also provides a method of treating a patient with cancer based on elevated expression levels of NFĸB, as measured by a H-score of the patients tumor sample using a NFĸB p65 IHC assay. The invention also provides a method of determining whether to treat a patient with a proteasome inhibitor based on the level of NFĸB p65 in the patient's tumor sample.
(FR)L'invention concerne une méthode de traitement du cancer au moyen d'un inhibiteur du protéasome. L'invention concerne également une méthode de traitement d'un patient souffrant d'un cancer basée sur des niveaux élevés d'expression de NFĸB, tels que mesurés par un score H de l'échantillon tumoral du patient au moyen d'un dosage NFĸB p65. L'invention concerne en outre une méthode pour déterminer si un patient doit être traité avec un inhibiteur du protéasome basée sur le niveau de NFĸB p65 dans l'échantillon tumoral du patient.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)