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Machine translation
1. (WO2013112528) METHODS AND COMPOSITIONS RELATING TO PROLIFERATIVE DISORDERS OF THE PROSTATE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/112528    International Application No.:    PCT/US2013/022667
Publication Date: 01.08.2013 International Filing Date: 23.01.2013
IPC:
C12Q 1/26 (2006.01), C12N 9/02 (2006.01), G01N 33/574 (2006.01), G01N 33/53 (2006.01)
Applicants: WEST CHESTER UNIVERSITY OF PENNSYLVANIA [--/US]; 700 South High Street Philips Memorial Building West Chester, PA 19383 (US).
BADER-SLUSHER, Leslie [US/US]; (US).
BENESKI, John, T., Jr. [US/US]; (US)
Inventors: BADER-SLUSHER, Leslie; (US).
BENESKI, John, T., Jr.; (US)
Agent: STAPLE, Julie, K.; Gifford, Krass, Sprinkle, Anderson & Citkowski, P.C. 2701 Troy Center Drive, Suite 330 Troy, MI 48007-7021 (US)
Priority Data:
61/589,490 23.01.2012 US
Title (EN) METHODS AND COMPOSITIONS RELATING TO PROLIFERATIVE DISORDERS OF THE PROSTATE
(FR) MÉTHODES ET COMPOSITIONS SE RAPPORTANT AUX TROUBLES PROLIFÉRATIFS DE LA PROSTATE
Abstract: front page image
(EN)Methods and kits for aiding in detection, assessment and treatment of a proliferative disorder of the prostate gland in a subject are provided according to aspects of the present invention which include assaying a first biological sample comprising prostate gland cells obtained from the subject for expression of one or more biomarkers selected from the group consisting of: alcohol dehydrogenase 1B, alcohol dehydrogenase 1C, alcohol dehydrogenase 4 and hepatocyte nuclear factor 1B; and determining, based on the expression of the one or more biomarkers in the sample that the subject has, or is at risk of having, a proliferative disorder of the prostate gland.
(FR)Selon certains aspects, la présente invention concerne des méthodes et des kits qui facilitent la détection, l'évaluation et le traitement d'un trouble prolifératif de la prostate chez un sujet, qui comprennent le dosage d'un premier échantillon biologique contenant des cellules prostatiques prélevées sur le sujet pour déterminer l'expression d'un ou de plusieurs biomarqueurs choisis dans le groupe constitué par : l'alcool déshydrogénase 1B, l'alcool déshydrogénase 1C, l'alcool déshydrogénase 4 et le facteur nucléaire hépatocytaire 1B; et la détermination, sur la base de l'expression d'un ou de plusieurs des biomarqueurs dans l'échantillon, du fait que le sujet est atteint ou court le risque d'être d'atteint d'un trouble prolifératif de la prostate.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)