Search International and National Patent Collections

1. (WO2013112456) CONTROLLED RELEASE FORMULATIONS FOR THE INDUCTION AND PROLIFERATION OF BLOOD CELLS

Pub. No.:    WO/2013/112456    International Application No.:    PCT/US2013/022518
Publication Date: Fri Aug 02 01:59:59 CEST 2013 International Filing Date: Wed Jan 23 00:59:59 CET 2013
IPC: A61K 9/64
A61K 38/19
A61K 47/48
A61K 38/16
A61K 31/436
A61K 31/203
A61P 37/00
A61P 37/06
Applicants: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Inventors: LITTLE, Steven, R.
RAIMONDI, Giorgio
THOMSON, Angus, W.
JHUNJHUNWALA, Siddharth
Title: CONTROLLED RELEASE FORMULATIONS FOR THE INDUCTION AND PROLIFERATION OF BLOOD CELLS
Abstract:
The absence of regulatory T cells (Treg) may underlie disorders including but not limited to autoimmunity, dermatitis, periodontitis and even transplant rejection. Enhancing local numbers of Treg through in situ Treg expansion or induction is contemplated herein as a treatment option for these disorders. Current methods for in vivo Treg expansion are not Treg specific and are associated with many adverse side-effects. The data presented herein provides in vitro testing of a Treg-inducing microparticle providing a predictable controlled release for combinations of cytokines and drugs (e.g., IL-2, TGF-β, and/or rapamycin) resulting in targeted Treg migration. These controlled release microparticles are also capable of inducing FoxP3+Treg in human cells in vitro suggesting that these compositions be developed into an in vivo Treg induction and expansion therapy.