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1. (WO2013111132) TREATMENT OF LIVER CONDITIONS

Pub. No.:    WO/2013/111132    International Application No.:    PCT/IL2013/050064
Publication Date: Fri Aug 02 01:59:59 CEST 2013 International Filing Date: Thu Jan 24 00:59:59 CET 2013
IPC: A61K 31/7076
A61P 1/16
A61P 35/00
Applicants: CAN-FITE BIOPHARMA LTD.
Inventors: FISHMAN, Pnina
COHEN, Shira
BAR-YEHUDA, Sara
Title: TREATMENT OF LIVER CONDITIONS
Abstract:
The present disclosure concerns the A3 adenosine receptor agonist, 2-Chloro-N6-(3-iodobenzyl)-adenosine-5'-N-methyluronamide (Cl-IB-MECA) in an amount of at least about 10mg/day, for use in treatment of hepatocellular carcinoma (HCC). The present invention also provides Cl-IB-MECA for use in maintenance of liver function in a subject having a chronic liver disease, such as cirrhosis. The liver function is considered as maintained if level of at least one physiological parameter indicative of liver function is essentially constant between two or more time points, i.e. the difference between the two time points does not exceed a medically acceptable tolerance.