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1. (WO2013110578) INTEGRIN ANTAGONIST CONJUGATES FOR TARGETED DELIVERY TO CELLS EXPRESSING ALPHA-V-BETA-3
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/110578    International Application No.:    PCT/EP2013/051082
Publication Date: 01.08.2013 International Filing Date: 22.01.2013
IPC:
A61K 47/48 (2006.01), A61P 35/00 (2006.01), A61P 29/00 (2006.01)
Applicants: F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel (CH) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
GOODNOW JR., Robert Alan [US/US]; (US) (US only).
HAMILTON, Matthew Michael [US/US]; (US) (US only).
KOWALCZYK, Agnieszka [US/US]; (US) (US only).
SIDDURI, Achyutharao [US/US]; (US) (US only)
Inventors: GOODNOW JR., Robert Alan; (US).
HAMILTON, Matthew Michael; (US).
KOWALCZYK, Agnieszka; (US).
SIDDURI, Achyutharao; (US)
Agent: TOWNSEND, Carolin; Grenzacherstrasse 124 CH-4070 Basel (CH)
Priority Data:
61/591,299 27.01.2012 US
61/678,669 02.08.2012 US
Title (EN) INTEGRIN ANTAGONIST CONJUGATES FOR TARGETED DELIVERY TO CELLS EXPRESSING ALPHA-V-BETA-3
(FR) CONJUGUÉS D'ANTAGONISTE DE L'INTÉGRINE POUR UNE ADMINISTRATION CIBLÉE À DES CELLULES EXPRIMANT L'ALPHA-V-BÊTA-3
Abstract: front page image
(EN)The invention relates to compounds of formula (I): wherein R1, R2, and n are defined in the detailed description and claims. In particular, the present invention relates to the compounds of formula (I) for use in the manufacture and delivery of conjugated moieties such as small molecules, peptides, nucleic acids, fluorescent moieties, and polymers which are linked to alpha-V-beta-3 integrin antagonists to target cells expressing alpha-V-beta-3.
(FR)La présente invention concerne des composés de formule (I):, R1, R2, et n étant définis dans la description détaillée et les revendications. En particulier, la présente invention porte sur les composés de formule (I) destinés à être utilisés dans la fabrication et l'administration de parties conjuguées ‑ telles que des petites molécules, des peptides, des acides nucléiques, des parties fluorescentes, et des polymères reliés à des antagonistes de l'intégrine alpha-V-bêta-3 - à des cellules ciblées exprimant l'alpha-V-bêta-3.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)