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1. (WO2013110163) COMPOSITIONS AND METHODS OF MODULATING AN IMMUNE RESPONSE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/110163 International Application No.: PCT/CA2012/050519
Publication Date: 01.08.2013 International Filing Date: 31.07.2012
IPC:
C07K 19/00 (2006.01) ,A61K 38/01 (2006.01) ,A61K 39/00 (2006.01) ,A61K 39/385 (2006.01) ,A61P 37/04 (2006.01) ,C07K 14/705 (2006.01) ,C07K 17/04 (2006.01) ,C12N 5/07 (2010.01) ,C12N 5/0784 (2010.01) ,C12Q 1/00 (2006.01)
Applicants: BIOMMUNE TECHNOLOGIES INC.[CA/CA]; 1640 Oak Bay Avenue Suite 202 Victoria, British Columbia V8R 1B2, CA
Inventors: JEFFERIES, Wilfred; CA
BASHA, Genc; CA
OMILUSIK, Kyla; CA
CHAVEZ-STEENBOCK, Ana; CA
Agent: MBM INTELLECTUAL PROPERTY LAW LLP; 270 Albert Street, 14th Floor Ottawa, Ontario K1P 5G8, CA
Priority Data:
61/591,41527.01.2012US
61/594,86303.02.2012US
Title (EN) COMPOSITIONS AND METHODS OF MODULATING AN IMMUNE RESPONSE
(FR) COMPOSITIONS ET MÉTHODES DE MODULATION DE RÉPONSE IMMUNITAIRE
Abstract:
(EN) Compositions for and methods of stimulating a M HC I mediated immune response comprising stimulating MHC I endolysosomal cross presentation in dendritic cells. Stimulation MHC I endolysosomal cross presentation may comprise over-expression CD74 in dendritic cells and/or targeting antigens to the MHC I endolysosomal cross presentation pathway. Fusion proteins comprising an antigen or fragment thereof and a CD74 endolysosomal targeting sequence are also provided.
(FR) L'invention concerne des compositions et des procédés pour stimuler une réponse immunitaire à médiation CMH I consistant à stimuler la présentation croisée endolysosomale de CMH I dans des cellules dendritiques. La stimulation de présentation croisée endolysosomale de CMH I peut comprendre une surexpression de CD74 dans les cellules dendritiques et/ou le ciblage d'antigènes sur la voie de la présentation croisée endolysosomale de CMH I. L'invention concerne également des protéines de fusion comprenant un antigène ou ses fragments et une séquence de ciblage endolysosomale de CD74.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)