WO2013109739 TRICYCLIC SULFONAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME

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Publication Number WO/2013/109739

Publication Date 25.07.2013

International Application No. PCT/US2013/021919

International Filing Date 17.01.2013

IPC

CPC

Applicants

ZAFGEN, INC. [US]/[US]

Inventors

PALLIN, Thomas David
DYKE, Hazel, Joan
CRAMP, Susan Mary
ZAHLER, Robert

Agents

KAVANAUGH, Theresa, C.

Priority Data

61/587,828

18.01.2012

Publication Language English (en)

Filing Language English (EN)

Designated States

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Title

(EN) TRICYCLIC SULFONAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME

(FR) COMPOSÉS SULFONAMIDES TRICYCLIQUES, PROCÉDÉS DE FABRICATION ET D'UTILISATION DE CEUX-CI

Abstract

(EN) The invention provides tricyclic sulfonamide compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.

(FR) La présente invention concerne des composés sulfonamides tricycliques et leur utilisation dans le traitement de troubles médicaux, tels que l'obésité. L'invention concerne également des compositions pharmaceutiques et des procédés de fabrication de divers composés tricycliques. Les composés selon l'invention présentent une activité contre la méthionyle aminopeptidase 2.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
491	Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02	in which the condensed system contains two hetero rings
04	Ortho-condensed systems
044	with only one oxygen atom as ring hetero atom in the oxygen-containing ring
052	the oxygen-containing ring being six-membered

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495	having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
50	Pyridazines; Hydrogenated pyridazines
5025	ortho- or peri-condensed with heterocyclic ring systems

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3	Drugs for disorders of the metabolism
04	Anorexiants; Antiobesity agents

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
491	Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02	in which the condensed system contains two hetero rings
04	Ortho-condensed systems
044	with only one oxygen atom as ring hetero atom in the oxygen-containing ring
052	the oxygen-containing ring being six-membered

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495	having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
50	Pyridazines; Hydrogenated pyridazines
5025	ortho- or peri-condensed with heterocyclic ring systems

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1. WO2013109739 - TRICYCLIC SULFONAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME