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1. (WO2013109735) TRICYCLIC SULFONE COMPOUNDS AND METHODS OF MAKING AND USING SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/109735 International Application No.: PCT/US2013/021914
Publication Date: 25.07.2013 International Filing Date: 17.01.2013
IPC:
C07D 311/78 (2006.01) ,A61K 31/353 (2006.01) ,A61P 3/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
311
Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02
ortho- or peri-condensed with carbocyclic rings or ring systems
78
Ring systems having three or more relevant rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
35
having six-membered rings with one oxygen as the only ring hetero atom
352
condensed with carbocyclic rings, e.g. cannabinols, methantheline
353
3,4-Dihydrobenzopyrans, e.g. chroman, catechin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
04
Anorexiants; Antiobesity agents
Applicants:
ZAFGEN, INC. [US/US]; One Broadway, 8th Floor Cambridge, MA 02142, US
Inventors:
PALLIN, Thomas, David; GB
DYKE, Hazel, Joan; GB
CRAMP, Susan, Mary; GB
ZAHLER, Robert; US
Agent:
KAVANAUGH, Theresa, C.; GOODWIN PROCTER LLP Exchange Place Boston, MA 02109, US
Priority Data:
61/587,82518.01.2012US
Title (EN) TRICYCLIC SULFONE COMPOUNDS AND METHODS OF MAKING AND USING SAME
(FR) COMPOSÉS SULFONES TRICYCLIQUES ET LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION
Abstract:
(EN) The invention provides tricyclic sulfone compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
(FR) L'invention concerne des composés sulfones tricycliques et leur utilisation dans le traitement de troubles médicaux, tels que l'obésité. L'invention concerne également des compositions pharmaceutiques et des procédés de fabrication de divers composés tricycliques. Il est envisagé que les composés ont une activité contre la méthionyl aminopeptidase 2.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)