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1. WO2013109316 - ENTERIC-COATED HT-2157 COMPOSITIONS AND METHODS OF THEIR USE

Publication Number WO/2013/109316
Publication Date 25.07.2013
International Application No. PCT/US2012/057418
International Filing Date 27.09.2012
IPC
A61K 9/22 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, lozenges or tablets
22Sustained or differential release type
CPC
A61K 9/2846
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
28Dragees; Coated pills or tablets ; , e.g. with film or compression coating
2806Coating materials
2833Organic macromolecular compounds
284obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
2846Poly(meth)acrylates
A61K 9/4891
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
4891Coated capsules; Multilayered drug free capsule shells
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/22
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
22Anxiolytics
A61P 25/24
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
24Antidepressants
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applicants
  • DART NEUROSCIENCE (CAYMAN) LTD. (AllExceptUS)
  • KAPLAN, Alan [US]/[US] (US)
Inventors
  • KAPLAN, Alan
Agents
  • PELTO, Don
Priority Data
13/354,42820.01.2012US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) ENTERIC-COATED HT-2157 COMPOSITIONS AND METHODS OF THEIR USE
(FR) COMPOSITIONS HT-2157 GASTRO-RÉSISTANTES ET LEURS PROCÉDÉS D'UTILISATION
Abstract
(EN) Drug compositions comprising the compound HT-2157 and their therapeutic uses, including the treatment of CNS disorders and cognitive impairments and the modulation of cognitive function, are disclosed. More particularly, the present invention relates to enteric-coated formulations comprising HT-2157 that reduce the appearance of clinically relevant methemoglobinemia relative to administration of non-enteric-coated formulations comprising HT-2157.
(FR) L'invention concerne des compositions médicamenteuses comprenant le composé HT-2157 et leurs utilisations thérapeutiques, comprenant le traitement de troubles du SNC et des déficits cognitifs et la modulation de la fonction cognitive. Plus particulièrement, la présente invention concerne des formulations gastro-résistantes comprenant HT-2157 qui réduisent l'apparence d'une méthémoglobunémie cliniquement pertinente par rapport à l'administration de formulations non gastro-résistantes comprenant HT-2157.
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