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1. WO2013106662 - TRANSGENEIC NON-HUMAN ANIMAL MODEL FOR ACCELERATED AGING AND/OR AGE-RELATED SYMPTOM, AND USE THEREOF

Publication Number WO/2013/106662
Publication Date 18.07.2013
International Application No. PCT/US2013/021165
International Filing Date 11.01.2013
IPC
A01K 67/00 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67Rearing or breeding animals, not otherwise provided for; New breeds of animals
C07H 21/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
CPC
A01K 2217/052
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2217Genetically modified animals
05Animals comprising random inserted nucleic acids (transgenic)
052inducing gain of function
A01K 2217/20
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2217Genetically modified animals
20Animal model comprising regulated expression system
A01K 2227/105
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2227Animals characterised by species
10Mammal
105Murine
A01K 2267/03
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2267Animals characterised by purpose
03Animal model, e.g. for test or diseases
A01K 67/0275
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67Rearing or breeding animals, not otherwise provided for; New breeds of animals
027New breeds of vertebrates
0275Genetically modified vertebrates, e.g. transgenic
C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
Applicants
  • ADVANCED GENOMIC TECHNOLOGY, LLC [US]/[US]
Inventors
  • WANG, Eugenia
Agents
  • STEIN, Michael, D.
Priority Data
61/586,29113.01.2012US
61/586,36113.01.2012US
61/636,47720.04.2012US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TRANSGENEIC NON-HUMAN ANIMAL MODEL FOR ACCELERATED AGING AND/OR AGE-RELATED SYMPTOM, AND USE THEREOF
(FR) MODÈLE D'ANIMAL TRANSGÉNIQUE NON HUMAIN POUR LE VIEILLISSEMENT ACCÉLÉRÉ ET/OU UN SYMPTÔME LIÉ À L'ÂGE, ET SON UTILISATION
Abstract
(EN)
A transgenic, non-human animal model for accelerated aging and/or age- related symptom, recombinant nucleic acid molecules, cells and methods that can be used to make such animal model and cells, methods of using the animal model and cells, to descendants of the transgenic non-human animal, obtained by breeding with the same or with another phenotype, and to a cell line or primary cell culture or to an organotypic brain slice culture, derived from the transgenic non-human animal or its descendants are disclosed.
(FR)
L'invention concerne un modèle d'animal transgénique non humain pour le vieillissement accéléré et/ou un symptôme lié à l'âge, des molécules d'acide nucléique recombiné, des cellules et des procédés qui peuvent être utilisés pour produire ce modèle animal et ces cellules, des procédés d'utilisation du modèle animal et des cellules, des descendants de l'animal non humain transgénique, obtenus par croisement avec le même phénotype ou un autre, et une lignée cellulaire ou une culture de cellules primaire ou une culture de tranche de cerveau organotypique, dérivée de l'animal non humain transgénique ou de ses descendants.
Also published as
Latest bibliographic data on file with the International Bureau