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1. WO2013105105 - NOVEL VIRAL VACCINE COMPOSITIONS AND METHODS FOR PREPARING SUCH VACCINES

Publication Number WO/2013/105105
Publication Date 18.07.2013
International Application No. PCT/IN2012/000701
International Filing Date 25.10.2012
IPC
A61K 39/15 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
15Reoviridae, e.g. calf diarrhea virus
CPC
A61K 2039/5252
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
525Virus
5252inactivated (killed)
A61K 2039/542
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
54characterised by the route of administration
541Mucosal route
542oral/gastrointestinal
A61K 2039/545
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
545characterised by the dose, timing or administration schedule
A61K 2039/55505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55505Inorganic adjuvants
A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61K 39/15
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
15Reoviridae, e.g. calf diarrhea virus
Applicants
  • SERUM INSTITUTE OF INDIA LTD. [IN]/[IN]
Inventors
  • DHERE, Rajeev Mhalasakant
  • ZADE, Jagdish Kamalaji
  • SABALE, Rajendra Narayan
Agents
  • WILSON, Neeti
Priority Data
135/MUM/201213.01.2012IN
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL VIRAL VACCINE COMPOSITIONS AND METHODS FOR PREPARING SUCH VACCINES
(FR) NOUVELLES COMPOSITIONS DE VACCINS VIRAUX ET MÉTHODES DE PRÉPARATION DE TELS VACCINS
Abstract
(EN) The invention provides a novel & cost-efficient process of concentrating rotavirus to obtain gel-adsorbed rotaviral liquid compositions, wherein the viral titer post-adsorption is atleast 10 fold greater than the pre-adsorption viral titer with partial removal of nucleic acid contaminants. Also present invention provides stable vaccine formulations of such live and inactivated rotavirus.
(FR) L'invention concerne un procédé nouveau et économique de concentration de rotavirus pour obtenir des compositions liquides rotavirales adsorbées sur gel, le titre viral après adsorption étant au moins 10 fois supérieur au titre viral avant adsorption avec élimination partielle de contaminants d'acides nucléiques. La présente invention concerne également des formulations vaccinales stables d'un tel rotavirus inactivé et vivant.
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