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1. (WO2013103306) BIOREACTOR COMPOSED OF WATERTIGHT CHAMBER AND INTERNAL MATRIX FOR THE GENERATION OF CELLULARIZED MEDICAL IMPLANTS

Pub. No.:    WO/2013/103306    International Application No.:    PCT/PT2013/000001
Publication Date: Fri Jul 12 01:59:59 CEST 2013 International Filing Date: Sat Jan 05 00:59:59 CET 2013
IPC: C12M 3/00
C12M 1/00
Applicants: A4TEC - ASSOCIATION FOR THE ADVANCEMENT OF TISSUE ENGINEERING AND CELL BASED TECHNOLOGIES &THERAPIES
Inventors: COSTA, Pedro Ferreira da
MARTINS, Albino Manuel, Pereira
VAQUETTE, Cedryck
NEVES, Nuno João Meleiro Alves das
GOMES, Maria Manuela Estima
HUTMACHER, Dietmar Werner
REIS, Rui Luís Gonçalves dos
MELCHELS, Ferry Petrus Wilhelmus
Title: BIOREACTOR COMPOSED OF WATERTIGHT CHAMBER AND INTERNAL MATRIX FOR THE GENERATION OF CELLULARIZED MEDICAL IMPLANTS
Abstract:
The present invention relates to a bioreactor for the generation of medical implants which comprises an external chamber, which can be unicompartmented 1 (preferably possessing two tubular structures 8) or multicompartmented, and watertight containing in its interior one or more matrices 7, the bioreactor' s internal matrices 7 and external chamber 1 being simultaneously manufactured, preferably through a rapid prototyping process; and also characterized by an external chamber 1 possessing a shape adapted to the shape of the implant to be cellularized (internal matrix) enabling a greater efficiency in the cellular colonization and culture of the implant, and by the implants being removed from the inside of the bioreactor by cutting the external chamber 1 in locations defined by grooves 9 right before implantation, allowing a greater sterility of the implant.