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1. (WO2013103306) BIOREACTOR COMPOSED OF WATERTIGHT CHAMBER AND INTERNAL MATRIX FOR THE GENERATION OF CELLULARIZED MEDICAL IMPLANTS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/103306 International Application No.: PCT/PT2013/000001
Publication Date: 11.07.2013 International Filing Date: 04.01.2013
IPC:
C12M 3/00 (2006.01) ,C12M 1/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3
Tissue, human, animal or plant cell, or virus culture apparatus
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1
Apparatus for enzymology or microbiology
Applicants:
A4TEC - ASSOCIATION FOR THE ADVANCEMENT OF TISSUE ENGINEERING AND CELL BASED TECHNOLOGIES &THERAPIES [PT/PT]; Universidade do Minho, Campus de Gualtar 470-057 Braga, PT
Inventors:
COSTA, Pedro Ferreira da; PT
MARTINS, Albino Manuel, Pereira; PT
VAQUETTE, Cedryck; FR
NEVES, Nuno João Meleiro Alves das; PT
GOMES, Maria Manuela Estima; PT
HUTMACHER, Dietmar Werner; AU
REIS, Rui Luís Gonçalves dos; PT
MELCHELS, Ferry Petrus Wilhelmus; AU
Agent:
SIMÕES, José Raúl de Magalhães; Rua Castilho, 167 - 2° 1070-050 Lisboa, PT
Priority Data:
10608305.01.2012PT
Title (EN) BIOREACTOR COMPOSED OF WATERTIGHT CHAMBER AND INTERNAL MATRIX FOR THE GENERATION OF CELLULARIZED MEDICAL IMPLANTS
(FR) BIORÉACTEUR COMPOSÉ DE CHAMBRE ÉTANCHE À L'EAU ET MATRICE INTERNE POUR LA GÉNÉRATION D'IMPLANTS MÉDICAUX CELLULARISÉS
Abstract:
(EN) The present invention relates to a bioreactor for the generation of medical implants which comprises an external chamber, which can be unicompartmented 1 (preferably possessing two tubular structures 8) or multicompartmented, and watertight containing in its interior one or more matrices 7, the bioreactor' s internal matrices 7 and external chamber 1 being simultaneously manufactured, preferably through a rapid prototyping process; and also characterized by an external chamber 1 possessing a shape adapted to the shape of the implant to be cellularized (internal matrix) enabling a greater efficiency in the cellular colonization and culture of the implant, and by the implants being removed from the inside of the bioreactor by cutting the external chamber 1 in locations defined by grooves 9 right before implantation, allowing a greater sterility of the implant.
(FR) La présente invention concerne un bioréacteur pour la génération d'implants médicaux. Le bioréacteur comprend une chambre externe pouvant avoir un seul compartiment (1) (possédant de préférence deux structures tubulaires (8)) ou plusieurs compartiments, et la chambre étanche à l'eau renfermant une ou plusieurs matrices (7), les matrices internes (7) du bioréacteur et une chambre externe (1) étant fabriqués simultanément, de préférence au moyen d'un procédé de prototypage rapide ; et également caractérisé par une chambre externe (1) possédant une forme adaptée à celle de l'implant à cellulariser (matrice interne), permettant ainsi une plus grande efficacité dans la colonisation cellulaire et la culture de l'implant, et le retrait des implants de l'intérieur du bioréacteur en coupant la chambre externe (1) à emplacements définis par les rainures (9) juste avant l'implantation, permettant une meilleure asepsie de l'implant.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)