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1. WO2013102936 - N-(3-((DIETHYLAMINO) METHYL)-4-HYDROXYPHENYL)-N-(QUINOLIN-4-YL) SULFONAMIDES FOR THE TREATMENT OF TUBERCULOSIS AND PROCESS OF PREPARATION THEREOF

Publication Number WO/2013/102936
Publication Date 11.07.2013
International Application No. PCT/IN2013/000006
International Filing Date 03.01.2013
IPC
C07D 215/44 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
38Nitrogen atoms
42attached in position 4
44with aryl radicals attached to said nitrogen atoms
C07D 409/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
A61K 31/4745 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
4738ortho- or peri-condensed with heterocyclic ring systems
4745condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
CPC
C07D 215/44
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
38Nitrogen atoms
42attached in position 4
44with aryl radicals attached to said nitrogen atoms
C07D 409/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Applicants
  • COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH [IN]/[IN]
Inventors
  • SINGH, Supriya
  • ROY, Kuldeep, Kumar
  • KHAN, Shaheb, Raj
  • KASHYAP, Vivek, Kumar
  • SHARMA, Sandeep, Kumar
  • KRISHNAN, Manju, Yasoda
  • CHATURVEDI, Vinita
  • SINHA, Sudhir, Kumar
  • SHRIVASTAVA, Ranjana
  • SAXENA, Anil, Kumar
Agents
  • DHAWAN, Ramesh, Chander
Priority Data
0014/DEL/201203.01.2012IN
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) N-(3-((DIETHYLAMINO) METHYL)-4-HYDROXYPHENYL)-N-(QUINOLIN-4-YL) SULFONAMIDES FOR THE TREATMENT OF TUBERCULOSIS AND PROCESS OF PREPARATION THEREOF
(FR) SULFAMIDES N-(3-((DIÉTHYLAMINO) MÉTHYL)-4-HYDROXYPHÉNYL)-N-(QUINOLIN-4-YL) UTILES POUR LE TRAITEMENT DE LA TURBERCULOSE ET PROCÉDÉ DE PRÉPARATION DE CES DERNIERS
Abstract
(EN) The present invention relates to novel N-(3-((diethylamino)methyl)-4-hydroxyphenyl)-N-(quinolin-4- yl)sulfonamide derivatives, their preparation, to pharmaceutical compositions comprising them, and to their use as therapeutic agents, particularly in the prevention or treatment of tuberculosis. The present invention particularly relates to compounds of formula A[Formula I]: wherein: R = methyl, (or) R = a group of the structure [Formula II] wherein, R1, R2, and R3 may be same or different present at any position(s) and are groups selected from the group consisting of hydrogen, halogen, alkyl (C1-C3), nitro, cyano, trifluoromethyl, (or) R is a group of the structure [Formula III] wherein X may be CH or N, and the attachment point of sulfonyl may be at the position 1 or 2, (or) R is a group of the structure [Formula IV] Where R1 is hydrogen or halogen, (or) R is a group of the structure. [Formula V]
(FR) La présente invention concerne de nouveaux dérivés de sulfamide N-(3-((diéthylamino)méthyl)-4-hydroxyphényl)-N-(quinolin-4- yl), la préparation de ces derniers, des compositions pharmaceutiques les contenant et leur utilisation en tant qu'agents thérapeutiques, notamment dans la prévention ou le traitement de la tuberculose. La présente invention porte plus particulièrement sur des composés représentés par la formule A, dans laquelle: R = méthyle, (ou) R = un groupe de la structure telle que, R1, R2, et R3 puissent être identiques ou différents, présents à n'importe laquelle des positions et soient des groupes sélectionnés dans le groupe formé par: hydrogène, halogène, alkyle (C1-C3), nitro, cyano, trifluorométhyle, (ou) R représente un groupe de la structure dans laquelle X peut représenter CH ou N, et le point de fixation de sulfonyle peut être à la position 1 ou 2, (ou) R représente un groupe de la structure dans laquelle R1 représente hydrogène ou halogène, (ou) R représente un groupe de la structure:
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