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1. WO2013102048 - REGENERATIVE TISSUE MATRIX

Publication Number WO/2013/102048
Publication Date 04.07.2013
International Application No. PCT/US2012/072027
International Filing Date 28.12.2012
IPC
A61F 2/02 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
02Prostheses implantable into the body
CPC
A61K 35/35
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
35Fat tissue; Adipocytes; Stromal cells; Connective tissues
A61K 35/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
36Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
A61L 2300/414
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2300Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
40characterised by a specific therapeutic activity or mode of action
412Tissue-regenerating or healing or proliferative agents
414Growth factors
A61L 2400/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2400Materials characterised by their function or physical properties
06Flowable or injectable implant compositions
A61L 27/362
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
36containing ingredients of undetermined constitution or reaction products thereof ; , e.g. transplant tissue, natural bone, extracellular matrix
3604characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
362Skin, e.g. dermal papillae
A61L 27/3687
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
36containing ingredients of undetermined constitution or reaction products thereof ; , e.g. transplant tissue, natural bone, extracellular matrix
3683subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
3687characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
Applicants
  • UNIVERSITY OF MIAMI [US]/[US]
Inventors
  • MORRIS, Paul, R.
  • KAST, Nathan
  • TEMPLE, H., Thomas
  • WOLFINBARGER, Lloyd
Agents
  • MALLOY, Jennie, S.
Priority Data
61/581,80330.12.2011US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) REGENERATIVE TISSUE MATRIX
(FR) MATRICE DE RÉGÉNÉRATION TISSULAIRE
Abstract
(EN) A process for the preparation of a tissue matrix suitable for regenerative repair of tissues, including contacting an isolated connective tissue with an amount of detergent and an amount of disinfectant to significantly reduce at least one of lipids, phospholipids, nucleic acids, major histocompatibility (MHC) antigens, contaminating microorganisms, and endotoxins. Also provided are kits comprising a prepared tissue matrix for use in regenerative repair, and kits for preparing a tissue matrix.
(FR) La présente invention concerne un procédé pour la préparation d'une matrice tissulaire appropriée pour la réparation et la régénération de tissus, comprenant la mise en contact de tissus conjonctifs isolés avec une quantité de détergent et une quantité de désinfectant pour la réduction significative d'au moins un parmi les lipides, phospholipides, acides nucléiques, antigènes du complexe majeur d'histocompatibilité (CMH), microorganismes contaminants, et endotoxines. Le procédé est également prévu pour une réduction moins significative dans la teneur en protéoglycane tout en maintenant la structure globale de la matrice tissulaire produite. Le traitement peut également comprendre la micronisation de la matrice tissulaire. L'invention concerne également une matrice tissulaire comprenant une partie d'échafaudage et une partie non structurelle, structurées conjointement pour promouvoir l'infiltration, la fixation, et la prolifération cellulaire. La matrice tissulaire peut être sous la forme d'une feuille, de feuille épaisse, ou micronisée. L'invention concerne en outre des trousses comportant une matrice tissulaire préparée destinée à être utilisée dans la réparation et la régénération, et des trousses pour la préparation d'une matrice tissulaire.
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