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1. WO2013083206 - DERIVATIVES OF 4-HYDROXY-1,2,3,4-TETRAHYDRONAPHTALEN-1-YL UREA AND THEIR USE IN THE TREATMENT OF, INTER ALIA, DISEASES OF THE RESPIRATORY TRACT

Publication Number WO/2013/083206
Publication Date 13.06.2013
International Application No. PCT/EP2011/072375
International Filing Date 09.12.2011
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
455
Nicotinic acid, i.e. niacin; Derivatives thereof, e.g. esters, amides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4196
1,2,4-Triazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
06
Antiasthmatics
C07D 403/12 (2006.01)
C07D 471/04 (2006.01)
A61K 31/455 (2006.01)
A61K 31/4196 (2006.01)
A61P 11/06 (2006.01)
CPC
A61K 9/007
C07D 401/12
C07D 403/12
C07D 471/04
Applicants
  • CHIESI FARMACEUTICI S.p.A. [IT/IT]; Via Palermo, 26/A I-43100 Parma, IT (AllExceptUS)
  • FINCH, Harry [GB/IT]; IT (UsOnly)
  • VAN NIEL, Monique Bodil [NL/IT]; IT (UsOnly)
  • WOO, Chi-Kit [GB/IT]; IT (UsOnly)
Inventors
  • FINCH, Harry; IT
  • VAN NIEL, Monique Bodil; IT
  • WOO, Chi-Kit; IT
Agents
  • MINOJA, Fabrizio; Bianchetti Bracco Minoja S.r.l. Via Plinio, 63 I-20129 Milano, IT
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DERIVATIVES OF 4-HYDROXY-1,2,3,4-TETRAHYDRONAPHTALEN-1-YL UREA AND THEIR USE IN THE TREATMENT OF, INTER ALIA, DISEASES OF THE RESPIRATORY TRACT
(FR) DÉRIVÉS DE 4-HYDROXY-1,2,3,4-TÉTRAHYDRONAPHTALÈNE-1-YL-URÉE ET LEUR UTILISATION DANS LE TRAITEMENT, ENTRE AUTRES, DE MALADIES DES VOIES RESPIRATOIRES
Abstract
(EN)
Disclosed are compounds having [1,2,4]triazolo[4,3-a] pyridine groups and pharmaceutically acceptable salts thereof. The compounds are p38 MAPK inhibitors, useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.
(FR)
L'invention concerne des composés comportant des groupes [1,2,4]triazolo[4,3-a]pyridine et des sels pharmaceutiquement acceptables de ceux-ci. Ces composés, qui sont des inhibiteurs de p38-MAPK, sont utilisés comme agents anti-inflammatoires dans le traitement, entre autres, de maladies des voies respiratoires.
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