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1. (WO2013063331) AGENTS, METHODS, AND DEVICES FOR AFFECTING NERVE FUNCTION
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/063331 International Application No.: PCT/US2012/062006
Publication Date: 02.05.2013 International Filing Date: 25.10.2012
IPC:
A61K 31/401 (2006.01) ,A61K 31/405 (2006.01) ,A61K 31/704 (2006.01) ,A61P 9/02 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
401
Proline; Derivatives thereof, e.g. captopril
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403
condensed with carbocyclic rings, e.g. carbazole
404
Indoles, e.g. pindolol
405
Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7028
Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
7034
attached to a carbocyclic compound, e.g. phloridzin
704
attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
02
Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
Applicants:
STEIN, Emily A. [US/US]; US
SWANSON, Christina D. [US/US]; US
EVANS, Michael A. [US/US]; US
VENKATESWARA-RAO, Kondapavulur T. [US/US]; US
Inventors:
STEIN, Emily A.; US
SWANSON, Christina D.; US
EVANS, Michael A.; US
VENKATESWARA-RAO, Kondapavulur T.; US
Agent:
SU, Jinn; 40087 Mission Boulevard #250 Fremont, California 94539, US
Priority Data:
61/551,92126.10.2011US
Title (EN) AGENTS, METHODS, AND DEVICES FOR AFFECTING NERVE FUNCTION
(FR) AGENTS, PROCÉDÉS ET DISPOSITIFS POUR AFFECTER LA FONCTION NERVEUSE
Abstract:
(EN) Agents, methods, and devices for affecting nerve function are described. One embodiment of an agent includes a cardiac glycoside, an ACE inhibitor, and an NSAID. The agent may be delivered locally in a site-specific manner to a targeted nerve or portion of a nerve. For example, the agent may be delivered locally to the renal nerves to impair their function and treat hypertension. One embodiment of a delivery device includes one or more needle housings supported by a balloon. A delivery needle is slidably disposed within a needle lumen of each needle housing.
(FR) L'invention concerne des agents, des procédés et des dispositifs pour affecter la fonction nerveuse. Un mode de réalisation d'un agent comprend un glycoside cardiaque, un inhibiteur d'ACE et un NSAID. L'agent peut être administré localement d'une manière spécifique à un site à un nerf ciblé ou à une partie d'un nerf. Par exemple, l'agent peut être administré localement aux nerfs rénaux pour altérer leur fonction et traiter l'hypertension. Un mode de réalisation d'un dispositif d'administration comprend un ou plusieurs boîtiers d'aiguille supportés par un ballonnet. Une aiguille d'administration est disposée de manière coulissante à l'intérieur d'une lumière d'aiguille de chaque boîtier d'aiguille.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)