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1. WO2013059750 - SAMPLE PREPARATION, PROCESSING AND ANALYSIS SYSTEMS

Publication Number WO/2013/059750
Publication Date 25.04.2013
International Application No. PCT/US2012/061223
International Filing Date 20.10.2012
IPC
C12M 1/00 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
CPC
B01L 2200/025
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2200Solutions for specific problems relating to chemical or physical laboratory apparatus
02Adapting objects or devices to another
025Align devices or objects to ensure defined positions relative to each other
B01L 2200/028
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2200Solutions for specific problems relating to chemical or physical laboratory apparatus
02Adapting objects or devices to another
028Modular arrangements
B01L 2200/04
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2200Solutions for specific problems relating to chemical or physical laboratory apparatus
04Exchange or ejection of cartridges, containers or reservoirs
B01L 2200/0647
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2200Solutions for specific problems relating to chemical or physical laboratory apparatus
06Fluid handling related problems
0647Handling flowable solids, e.g. microscopic beads, cells, particles
B01L 2200/143
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2200Solutions for specific problems relating to chemical or physical laboratory apparatus
14Process control and prevention of errors
143Quality control, feedback systems
B01L 2300/023
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2300Additional constructional details
02Identification, exchange or storage of information
023Sending and receiving of information, e.g. using bluetooth
Applicants
  • INTEGENX INC. [US]/[US] (AllExceptUS)
  • NIELSEN, Willian, D. [US]/[US] (US)
  • BELCINSKI, Richard, J. [US]/[US] (US)
  • BOGDAN, Gregory [US]/[US] (US)
  • EBERHART, David [US]/[US] (US)
  • EL-SISSI, Omar [US]/[US] (US)
  • JOVANOVICH, Stevan, B. [US]/[US] (US)
  • RECKNOR, Michael [US]/[US] (US)
  • VAN GELDER, Ezra [NL]/[US] (US)
  • WYRICK, David, W. [US]/[US] (US)
Inventors
  • NIELSEN, Willian, D.
  • BELCINSKI, Richard, J.
  • BOGDAN, Gregory
  • EBERHART, David
  • EL-SISSI, Omar
  • JOVANOVICH, Stevan, B.
  • RECKNOR, Michael
  • VAN GELDER, Ezra
  • WYRICK, David, W.
Agents
  • DINH, Tam
Priority Data
13/656,50319.10.2012US
61/550,36421.10.2011US
61/605,16929.02.2012US
61/610,97714.03.2012US
61/641,12001.05.2012US
61/654,74901.06.2012US
61/664,72626.06.2012US
61/671,59213.07.2012US
61/674,29520.07.2012US
61/691,24220.08.2012US
61/696,13231.08.2012US
61/696,80905.09.2012US
61/697,80306.09.2012US
61/703,19419.09.2012US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) SAMPLE PREPARATION, PROCESSING AND ANALYSIS SYSTEMS
(FR) SYSTÈMES DE PRÉPARATION, DE TRAITEMENT ET D'ANALYSE D'ÉCHANTILLONS
Abstract
(EN) This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.
(FR) Cette invention concerne un système intégré et automatisé d'échantillon-à-réponse qui, à partir d'un échantillon comprenant une matière biologique, génère un profil génétique en moins de deux heures. Dans certains modes de réalisation, la matière biologique est de l'ADN et le profil génétique met en jeu la détermination d'allèles à un ou plusieurs loci (par exemple des loci génétiques) d'un sujet, par exemple, un profil STR (courte répétition en tandem), par exemple tel qu'utilisé dans le système CODIS. Le système peut mettre en œuvre plusieurs opérations, comprenant (a) une extraction et un isolement d'acide nucléique; (b) une amplification de séquences nucléotidiques à des loci choisis (par exemple des loci génétiques); et (c) une détection et une analyse de produit d'amplification. Ces opérations peuvent être effectuées dans un système qui comprend plusieurs modules intégrés, comprenant un module de préparation d'analyte, un module de détection et d'analyse et un module de commande.
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