WO2013059740 NOVEL ALK AND NTRK1 FUSION MOLECULES AND USES THEREOF

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Publication Number WO/2013/059740

Publication Date 25.04.2013

International Application No. PCT/US2012/061211

International Filing Date 19.10.2012

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CPC

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Applicants

FOUNDATION MEDICINE, INC. [US]/[US]

Inventors

YELENSKY, Roman
LIPSON, Doron
CRONIN, Maureen

Agents

COLLAZO, Diana M.

Priority Data

61/550,327

21.10.2011

Publication Language English (en)

Filing Language English (EN)

Designated States

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Title

(EN) NOVEL ALK AND NTRK1 FUSION MOLECULES AND USES THEREOF

(FR) NOUVELLES MOLÉCULES DE FUSION ALK ET NTRK1 ET LEURS UTILISATIONS

Abstract

(EN) Novel ALK and NTRKl fusion molecules and uses are disclosed.

(FR) L'invention concerne de nouvelles molécules de fusion ALK et NTRK1 et leurs utilisations.

Latest bibliographic data on file with the International Bureau

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P	FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21	Preparation of peptides or proteins
02	having a known sequence of two or more amino acids, e.g. glutathione

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
H	SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21	Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04	with deoxyribosyl as saccharide radical

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P	FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21	Preparation of peptides or proteins
02	having a known sequence of two or more amino acids, e.g. glutathione

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
H	SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21	Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04	with deoxyribosyl as saccharide radical

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435	having six-membered rings with one nitrogen as the only ring hetero atom
44	Non condensed pyridines; Hydrogenated derivatives thereof
445	Non condensed piperidines, e.g. piperocaine
4523	containing further heterocyclic ring systems
4545	containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine

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1. WO2013059740 - NOVEL ALK AND NTRK1 FUSION MOLECULES AND USES THEREOF

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
14	Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435	from animals; from humans
46	from vertebrates
47	from mammals
4701	not used
4738	Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9	Enzymes; Proenzymes; Compositions thereof
10	Transferases (2.)
12	transferring phosphorus containing groups, e.g. kinases (2.7)

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q	MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1	Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68	involving nucleic acids
6876	Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883	for diseases caused by alterations of genetic material
6886	for cancer

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Y	ENZYMES
207	Transferases transferring phosphorus-containing groups (2.7)
10	Protein-tyrosine kinases (2.7.10)
10001	Receptor protein-tyrosine kinase (2.7.10.1)

G	PHYSICS
01	MEASURING; TESTING
N	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33	Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48	Biological material, e.g. blood, urine
50	Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
5005	involving human or animal cells
5008	for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
5011	for testing antineoplastic activity

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
16	Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
40	against enzymes

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
16	Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
40	against enzymes