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1. WO2013059644 - METHOD TO MEASURE INFLAMMATION IN THE CONJUNCTIVA OF PATIENTS WITH TEAR DYSFUNCTION

Publication Number WO/2013/059644
Publication Date 25.04.2013
International Application No. PCT/US2012/061095
International Filing Date 19.10.2012
IPC
C12N 5/00 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
CPC
C12Q 1/686
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6844Nucleic acid amplification reactions
686Polymerase chain reaction [PCR]
C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
C12Q 2600/158
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
158Expression markers
Applicants
  • BAYLOR COLLEGE OF MEDICINE [US]/[US] (AllExceptUS)
Inventors
  • PFLUGRELDER, Stephen, C.
  • DE PAIVA, Cintia, S.
  • CORRALES HERRAN, Rosa, M.
  • LI, De-quan
Agents
  • SISTRUNK, Melissa, L.
Priority Data
61/549,78121.10.2011US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHOD TO MEASURE INFLAMMATION IN THE CONJUNCTIVA OF PATIENTS WITH TEAR DYSFUNCTION
(FR) PROCÉDÉ POUR LA MESURE DE L'INFLAMMATION DANS LA CONJONCTIVE DE PATIENTS PRÉSENTANT UN DYSFONCTIONNEMENT DES LARMES
Abstract
(EN) The present invention concerns methods and compositions for treatment and determination of the presence or likelihood of an individual to have an ocular surface inflammation. In specific embodiments, a sample from the individual is assayed for the expression level of three or more genes, including IL-6, MMP3, MMP9, IFNy, SPRR-IA, HLA-DRA, MUC5AC, K7, and IL17A. Treatment is provided to an individual with ocular surface inflammatiojn based upon the gene analysis.
(FR) La présente invention concerne des méthodes et des compositions pour le traitement et la détermination de la présence ou de la susceptibilité d'un individu à présenter une inflammation de la surface oculaire. Dans des modes de réalisation spécifiques, l'invention concerne un échantillon provenant de l'individu qui est dosé pour le taux d'expression d'au moins trois gènes, comprenant IL-6, MMP3, MMP9, IFNy, SPRR-IA, HLA-DRA, MUC5AC, K7 et IL17A. Le traitement est fourni à un individu présentant une inflammation de la surface oculaire sur la base de l'analyse génétique.
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