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1. (WO2013059475) ALKYNYL-DERIVATIZED CAP ANALOGS, PREPARATION AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/059475    International Application No.:    PCT/US2012/060832
Publication Date: 25.04.2013 International Filing Date: 18.10.2012
IPC:
C07H 21/02 (2006.01), C12N 15/67 (2006.01)
Applicants: LIFE TECHNOLOGIES CORPORATION [US/US]; 5791 Van Allen Way Carlsbad, California 92008 (US)
Inventors: KORE, Anilkumar; (US).
MUTHIAN, Shanmugasundaram; (US).
GEE, Kyle; (US)
Agent: NORBERG, Gloria; Life Technologies Corporation 5791 Van Allen Way Carlsbad, California 92008 (US)
Priority Data:
61/548,653 18.10.2011 US
Title (EN) ALKYNYL-DERIVATIZED CAP ANALOGS, PREPARATION AND USES THEREOF
(FR) ANALOGUES DE COIFFES À DÉRIVATION ALCYNYLE, PRÉPARATION ET UTILISATIONS ASSOCIÉES
Abstract: front page image
(EN)Alkynyl-derivatized cap analogs, alkynyl-modified capped RNA, 1,4-disubstituted triazole-derivatized capped RNA, methods of preparation, methods of isolation, and uses thereof are provided. The "click" modification facilitates detection and isolation of capped RNAs and the 1,4-disubstituted triazole derivatives formed by the "click" reaction are useful for producing RNA transcripts and encoded protein.
(FR)La présente invention concerne des analogues de coiffes à dérivation alcynyle, un ARN coiffé à modification alcynyle, un ARN coiffé à dérivation 1,4-triazole bisubstitué, des procédés de préparation, des procédés d'isolement et des utilisations associées. La modification dite « click » facilite la détection et l'isolement des ARN coiffés et les dérivés de 1,4-triazole bisubstitué formés par la réaction dite « click » sont utiles pour produire des ARN transcrits et une protéine codée.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)