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1. (WO2013059411) METHOD FOR TREATING CANCER WITH TOXOPLASMA GONDII VACCINE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/059411    International Application No.:    PCT/US2012/060746
Publication Date: 25.04.2013 International Filing Date: 18.10.2012
IPC:
A61K 39/12 (2006.01), A61K 39/00 (2006.01)
Applicants: TRUSTEES OF DARTMOUTH COLLEGE [US/US]; Technology Transfer Office 11 Rope Ferry Road Hanover, NH 03755 (US)
Inventors: BZIK, David, J.; (US).
FOX, Barbara; (US).
FIERING, Steven, N.; (US).
CONEJO-GARCIA, Jose, R.; (US).
BAIRD, Jason; (US).
SANDERS, Kiah, L.; (US)
Agent: LICATA, Jane, Massey; Licata & Tyrrell P.C. 66 E. Main Street Marlton, NJ 08053 (US)
Priority Data:
13/276,577 19.10.2011 US
Title (EN) METHOD FOR TREATING CANCER WITH TOXOPLASMA GONDII VACCINE
(FR) MÉTHODE DE TRAITEMENT DU CANCER AU MOYEN D'UN VACCIN CONTENANT TOXOPLASMA GONDII
Abstract: front page image
(EN)The disclosure provides attenuated Toxoplasma gondii mutants for use as vaccines or treatment of cancer. More specifically, the attenuated mutants include a knockout mutation of one or more genes of the de novo pyrimidine synthesis pathway, or are generated by gamma-irradiation. Further disclosed are cancers that can be treated with the attenuated mutants.
(FR)L'invention concerne des mutants atténués de Toxoplasma gondii destinés à être utilisés comme vaccins ou en traitement du cancer. Plus particulièrement, les mutants atténués comprennent une mutation inactivatrice d'un ou de plusieurs gènes de la voie de synthèse de novo de la pyrimidine, ou sont générés par irradiation gamma. L'invention porte également sur des cancers qui peuvent être traités au moyen de ces mutants atténués.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)