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1. (WO2013059245) INDOMETHACIN ANALOGS FOR THE TREATMENT OF CASTRATE-RESISTANT PROSTATE CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/059245    International Application No.:    PCT/US2012/060508
Publication Date: 25.04.2013 International Filing Date: 17.10.2012
IPC:
A61K 31/405 (2006.01), C07D 209/26 (2006.01)
Applicants: VANDERBILT UNIVERSITY [US/US]; Center for Technology Transfer & Commercialization 305 Kirkland Hall 2201 West End Avenue Nashville, TN 37240 (US).
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US/US]; 3160 Chestnut Street, Suite 200 Philadelphia, 19104 (US)
Inventors: MARNETT, Lawrence, J.; (US).
LIEDTKE, Andy, J.; (US).
PENNING, Trevor, M.; (US).
ADENIJI, Adegoke, O.; (US).
BYRNS, Michael, C.; (US)
Agent: PERKINS, Christopher, P.; Jenkins, Wilson, Taylor & Hunt, P.A. Suite 1200, University Tower 3100 Tower Boulevard Durham, NC 27707 (US)
Priority Data:
61/548,004 17.10.2011 US
Title (EN) INDOMETHACIN ANALOGS FOR THE TREATMENT OF CASTRATE-RESISTANT PROSTATE CANCER
(FR) ANALOGUES DE L'INDOMÉTACINE DESTINÉS AU TRAITEMENT DU CANCER DE LA PROSTATE RÉSISTANT À LA CASTRATION
Abstract: front page image
(EN)Provided are compositions for inhibiting a biological activity of an aldoketo reductase family 1, member C3 (AKR1 C3) polypeptide. In some embodiments, the compositions are indomethacin derivatives that are AKR1 C3-specific inhibitors. Also provided are methods for producing disclosed indomethacin derivatives that substantially lack cyclooxygenase inhibitory activity but that have AKR1C3 inhibitory activity, methods for inhibiting AKR1C3 polypeptide biological activities, and methods for treating prostate tumors in subjects.
(FR)L'invention concerne des compositions destinées à inhiber l'activité biologique d'un polypeptide du membre C3 (AKR1 C3) de la famille 1 des aldocéto-réductases. Dans certaines formes de réalisation, les compositions sont des dérivés de l'indométacine constituant des inhibiteurs spécifiques d'AKR1 C3. L'invention concerne aussi des procédés de production des dérivés décrits de l'indométacine qui sont sensiblement dépourvus d'activité d'inhibition de la cyclooxygénase, mais possèdent une activité d'inhibition d'AKR1C3, des procédés visant à inhiber les activités biologiques du polypeptide AKR1C3 et des méthodes de traitement de tumeurs de la prostate chez des sujets.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)