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Machine translation
1. (WO2013058812) TARGETED DELIVERY TO PANCREATIC ISLET ENDOTHELIAL CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/058812    International Application No.:    PCT/US2012/023619
Publication Date: 25.04.2013 International Filing Date: 02.02.2012
IPC:
A61K 47/48 (2006.01), A61K 9/16 (2006.01), A61K 9/14 (2006.01), A61K 39/395 (2006.01), A61P 29/00 (2006.01)
Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US/US]; 17 Quincy Street Cambridge, Massachusetts 02138 (US) (For All Designated States Except US).
CHILDREN'S MEDICAL CENTER CORPORATION [US/US]; 55 Shattuck Street Boston, MA 02115 (US) (For All Designated States Except US).
INGBER, Donald, E. [US/US]; (US) (For US Only).
GHOSH, Kaustabh [IN/US]; (US) (For US Only).
KANAPATHIPILLAI, Mathumai [LK/US]; (US) (For US Only)
Inventors: INGBER, Donald, E.; (US).
GHOSH, Kaustabh; (US).
KANAPATHIPILLAI, Mathumai; (US)
Agent: RESNICK, David S.; Nixon Peabody LLP 100 Summer St. Boston, MA 02110 (US)
Priority Data:
61/549,042 19.10.2011 US
61/585,116 10.01.2012 US
Title (EN) TARGETED DELIVERY TO PANCREATIC ISLET ENDOTHELIAL CELLS
(FR) ADMINISTRATION CIBLÉE À DES CELLULES ENDOTHÉLIALES D'ÎLOTS PANCRÉATIQUES
Abstract: front page image
(EN)The present invention provides, in part, compositions and methods of targeted delivery of an agent or cells to islet endothelial cells in the pancreas using a novel islet-targeting molecule. Accordingly, one aspect of the present invention provides a composition comprising a carrier particle attached to an islet targeting molecule, wherein an agent is associated with the carrier particle, and is therefore targeted to islet cells by the islet targeting molecule. In some embodiments, the islet targeting molecule is an islet-targeting peptide. In some embodiments, such a carrier particle is a nanoparticle or similar.
(FR)La présente invention concerne, en partie, des compositions et des méthodes d'administration ciblée d'un agent ou de cellules à des cellules endothéliales d'îlots présentes dans le pancréas en utilisant une nouvelle molécule ciblant les îlots. Par conséquent, un aspect de la présente invention concerne une composition comprenant une particule de transport liée à une molécule ciblant les îlots, un agent étant associé à la particule de transport, et étant donc ciblé sur les cellules d'îlots par le biais de la molécule ciblant les îlots. Dans certains modes de réalisation, la molécule ciblant les îlots est un peptide ciblant les îlots. Dans certains modes de réalisation, une telle particule de transport est une nanoparticule ou une particule similaire.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)