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1. (WO2013058632) COMPOSITION CONTAINING OHIOENSINS F AS A POLYTRICHASTRUM ALPINUM-DERIVED NOVEL COMPOUND FOR PREVENTING OR TREATING ARTERIOSCLEROSIS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/058632    International Application No.:    PCT/KR2012/008686
Publication Date: 25.04.2013 International Filing Date: 22.10.2012
IPC:
A61K 31/352 (2006.01), A61K 31/35 (2006.01), A61P 9/10 (2006.01), A61P 9/00 (2006.01)
Applicants: KOREA INSTITUTE OF OCEAN SCIENCE AND TECHNOLOGY [KR/KR]; 787 (Sa-dong), Haean-ro Sangrok-gu, Ansan-si Gyeonggi-do 426-170 (KR)
Inventors: YIM, Joung Han; (KR).
KIM, Il-chan; (KR).
KIM, Dockyu; (KR).
HAN, Se Jong; (KR).
LEE, Hyoung Seok; (KR).
OH, Hyun Cheol; (KR).
PYO, Suhkneung; (KR)
Agent: LEE, Cheo Young; 11th, Yeosam Bldg. 648-23, Yeoksam-dong, Gangnam-gu Seoul 135-080 (KR)
Priority Data:
10-2011-0107526 20.10.2011 KR
Title (EN) COMPOSITION CONTAINING OHIOENSINS F AS A POLYTRICHASTRUM ALPINUM-DERIVED NOVEL COMPOUND FOR PREVENTING OR TREATING ARTERIOSCLEROSIS
(FR) COMPOSITIONS CONTENANT DE L'OHIOENSINE F EN TANT QUE NOUVEAU COMPOSÉ DÉRIVÉ DE POLYTRICHASTRUM ALPINUM POUR PRÉVENIR OU TRAITER L'ARTÉRIOSCLÉROSE
(KO) 폴리트리카스트럼 알피넘 유래 신규 화합물 오하이오넨신 F를 함유하는 동맥경화증 예방 또는 치료용 조성물
Abstract: front page image
(EN)The present invention relates to a composition containing extracts of polytrichastrum alpinum for preventing or treating arteriosclerosis. More particularly, the present invention relates to a pharmaceutical composition containing, as an active ingredient, ohioensins F which is a benzonaphthoxanthenone-based compound separated from Antarctic lichens polytrichastrum alpinum, for preventing or treating arteriosclerosis. The composition containing ohioensins F which is a benzonaphthoxanthenone-based compound derived from polytrichastrum alpinum according to the present invention may inhibit an expression of cell adhesion molecules induced by TNF-α, and therefore, can be valuably used in treating and preventing arteriosclerosis.
(FR)La présente invention concerne une composition contenant des extraits de polytrichastrum alpinum pour prévenir ou traiter l'artériosclérose. Plus particulièrement, la présente invention concerne une composition pharmaceutique contenant, en tant que principe actif, de l'ohioensine F qui est un composé à base de benzonaphthoxanthenone dérivé de lichens d'Antarctique polytrichastrum alpinum, pour prévenir ou traiter l'artériosclérose. La composition contenant l'ohioensine F, un composé à base de benzonaphthoxanthenone dérivé de polytrichastrum alpinum, peut inhiber une expression des molécule d'adhésion cellulaire induite par TNF-α, et de ce fait, elle peut être avantageusement utilisée pour traiter et prévenir l'artériosclérose.
(KO)본 발명은 폴리트리카스트럼 알피넘 추출물을 함유하는 동맥경화증 예방 또는 치료용 조성물에 관한 것으로, 보다 상세하게는 남극 이끼류인 폴리트리카스트럼 알피넘으로부터 분리된 벤조나프토크산테논계 화합물 오하이오넨신 F를 유효성분으로 함유하는 동맥경화증 예방 또는 치료용 약학 조성물에 관한 것이다. 본 발명에 따른 폴리트리카스트럼 알피넘(Polytrichastrum alpinum) 추출물 유래 벤조나프토크산테논계 화합물 오하이오넨신 F가 함유된 조성물은 TNF-α에 의해 유도되는 세포부착분자의 발현을 억제시킴으로써, 동맥경화증 치료 및 예방에 유용하게 사용할 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)