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1. WO2013058632 - COMPOSITION CONTAINING OHIOENSINS F AS A POLYTRICHASTRUM ALPINUM-DERIVED NOVEL COMPOUND FOR PREVENTING OR TREATING ARTERIOSCLEROSIS

Publication Number WO/2013/058632
Publication Date 25.04.2013
International Application No. PCT/KR2012/008686
International Filing Date 22.10.2012
IPC
A61K 31/352 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 31/35 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
A61P 9/10 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A61P 9/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
CPC
A23L 33/105
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
105Plant extracts, their artificial duplicates or their derivatives
A23V 2002/00
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES
2002Food compositions, function of food ingredients or processes for food or foodstuffs
A61K 31/35
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
A61K 31/352
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 36/062
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
06Fungi, e.g. yeasts
062Ascomycota
A61K 9/146
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
146with organic macromolecular compounds
Applicants
  • 한국해양과학기술원 KOREA INSTITUTE OF OCEAN SCIENCE AND TECHNOLOGY [KR]/[KR]
Inventors
  • 임정한 YIM, Joung Han
  • 김일찬 KIM, Il-chan
  • 김덕규 KIM, Dockyu
  • 한세종 HAN, Se Jong
  • 이형석 LEE, Hyoung Seok
  • 오현철 OH, Hyun Cheol
  • 표석능 PYO, Suhkneung
Agents
  • 이처영 LEE, Cheo Young
Priority Data
10-2011-010752620.10.2011KR
Publication Language Korean (ko)
Filing Language Korean (KO)
Designated States
Title
(EN) COMPOSITION CONTAINING OHIOENSINS F AS A POLYTRICHASTRUM ALPINUM-DERIVED NOVEL COMPOUND FOR PREVENTING OR TREATING ARTERIOSCLEROSIS
(FR) COMPOSITIONS CONTENANT DE L'OHIOENSINE F EN TANT QUE NOUVEAU COMPOSÉ DÉRIVÉ DE POLYTRICHASTRUM ALPINUM POUR PRÉVENIR OU TRAITER L'ARTÉRIOSCLÉROSE
(KO) 폴리트리카스트럼 알피넘 유래 신규 화합물 오하이오넨신 F를 함유하는 동맥경화증 예방 또는 치료용 조성물
Abstract
(EN) The present invention relates to a composition containing extracts of polytrichastrum alpinum for preventing or treating arteriosclerosis. More particularly, the present invention relates to a pharmaceutical composition containing, as an active ingredient, ohioensins F which is a benzonaphthoxanthenone-based compound separated from Antarctic lichens polytrichastrum alpinum, for preventing or treating arteriosclerosis. The composition containing ohioensins F which is a benzonaphthoxanthenone-based compound derived from polytrichastrum alpinum according to the present invention may inhibit an expression of cell adhesion molecules induced by TNF-α, and therefore, can be valuably used in treating and preventing arteriosclerosis.
(FR) La présente invention concerne une composition contenant des extraits de polytrichastrum alpinum pour prévenir ou traiter l'artériosclérose. Plus particulièrement, la présente invention concerne une composition pharmaceutique contenant, en tant que principe actif, de l'ohioensine F qui est un composé à base de benzonaphthoxanthenone dérivé de lichens d'Antarctique polytrichastrum alpinum, pour prévenir ou traiter l'artériosclérose. La composition contenant l'ohioensine F, un composé à base de benzonaphthoxanthenone dérivé de polytrichastrum alpinum, peut inhiber une expression des molécule d'adhésion cellulaire induite par TNF-α, et de ce fait, elle peut être avantageusement utilisée pour traiter et prévenir l'artériosclérose.
(KO) 본 발명은 폴리트리카스트럼 알피넘 추출물을 함유하는 동맥경화증 예방 또는 치료용 조성물에 관한 것으로, 보다 상세하게는 남극 이끼류인 폴리트리카스트럼 알피넘으로부터 분리된 벤조나프토크산테논계 화합물 오하이오넨신 F를 유효성분으로 함유하는 동맥경화증 예방 또는 치료용 약학 조성물에 관한 것이다. 본 발명에 따른 폴리트리카스트럼 알피넘(Polytrichastrum alpinum) 추출물 유래 벤조나프토크산테논계 화합물 오하이오넨신 F가 함유된 조성물은 TNF-α에 의해 유도되는 세포부착분자의 발현을 억제시킴으로써, 동맥경화증 치료 및 예방에 유용하게 사용할 수 있다.
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