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1. (WO2013056684) THIAZOLE DERIVATIVE AS DHODH INHIBITOR AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/056684    International Application No.:    PCT/CN2012/086816
Publication Date: 25.04.2013 International Filing Date: 18.12.2012
IPC:
C07D 275/02 (2006.01), C07D 401/02 (2006.01), C07D 417/12 (2006.01), C07D 401/12 (2006.01), A61K 31/426 (2006.01), A61K 31/435 (2006.01), A61P 19/02 (2006.01), A61P 35/00 (2006.01), A61P 37/06 (2006.01), A61P 37/00 (2006.01), A61P 17/06 (2006.01)
Applicants: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY [CN/CN]; 130 Meilong Road Shanghai 200237 (CN)
Inventors: ZHAO, Zhenjiang; (CN).
HUANG, Jin; (CN).
LI, Honglin; (CN).
XU, Yufang; (CN).
ZHU, Lili; (CN).
HAN, Le; (CN).
XU, Minghao; (CN).
GAO, Rui; (CN).
DIAO, Yanyan; (CN).
ZHU, Junsheng; (CN).
CAO, Xianwen; (CN).
CUI, Kunqiang; (CN)
Agent: SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC; 435 Guiping Road Shanghai 200233 (CN)
Priority Data:
201110317124.9 18.10.2011 CN
Title (EN) THIAZOLE DERIVATIVE AS DHODH INHIBITOR AND USE THEREOF
(FR) DÉRIVÉ DE THIAZOLE EN TANT QU'INHIBITEUR DE LA DHODH ET SON UTILISATION
(ZH) 作为DHODH抑制剂的噻唑衍生物及其应用
Abstract: front page image
(EN)A thiazole derivative, as represented in formula I, as a DHODH inhibitor and a use thereof. The compound of the present invention can be used for treating or preventing DHODH-mediated diseases, including, but not limited to, rheumatoid arthritis and autoimmune diseases such as anti-tumor, anti-organ transplant rejection, and anti-psoriasis.
(FR)L'invention concerne un dérivé de thiazole, représenté par la formule I, en tant qu'inhibiteur de la DHODH, ainsi que l'utilisation de ce dérivé. Le composé de la présente invention permet le traitement ou la prévention de maladies à médiation DHODH, notamment mais non exclusivement de la polyarthrite rhumatoïde et des maladies auto-immunes telles que tumeurs, rejets de greffe d'organe et psoriasis.
(ZH)通式 I 所示的DHODH抑制剂的噻唑衍生物及其应用。本发明的化合物能用于治疗或预防DHODH介导的各种疾病,包括但不限于类风湿关节炎、抗肿瘤、抗器官移植排异、抗牛皮癣等多种自身免疫性疾病。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)