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1. (WO2013056229) THE USE OF (2R, 6R)-HYDROXYNORKETAMINE, (S)-DEHYDRONORKETAMINE AND OTHER STEREOISOMERIC DEHYDRO AND HYDROXYLATED METABOLITES OF (R,S)- KETAMINE IN THE TREATMENT OF DEPRESSION AND NEUROPATHIC PAIN
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/056229    International Application No.:    PCT/US2012/060256
Publication Date: 18.04.2013 International Filing Date: 15.10.2012
IPC:
C07C 225/20 (2006.01), C07C 237/02 (2006.01), C07D 295/155 (2006.01), C07D 295/145 (2006.01), A61P 25/04 (2006.01), A61P 25/28 (2006.01), A61P 25/00 (2006.01), A61K 31/133 (2006.01), A61K 31/122 (2006.01)
Applicants: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; National Institutes of Health Office of Technology Transfer 6011 Executive Boulevard Suite 325, MSC 7660 Bethesda, Maryland 20892-7660 (US).
THE COOPER HEALTH SYSTEM [US/US]; One Cooper Plaza Camden, New Jersey 08103 (US).
WAINER, Irving W. [US/US]; (US) (US only).
MOADDEL, Ruin [US/US]; (US) (US only).
BERNIER, Michel [US/US]; (US) (US only).
ZARATE, Carlos A. [US/US]; (US) (US only).
TORJMAN, Marc C. [US/US]; (US) (US only).
GOLDBERG, Michael E. [US/US]; (US) (US only).
TANGA, Mary J. [US/US]; (US) (US only)
Inventors: WAINER, Irving W.; (US).
MOADDEL, Ruin; (US).
BERNIER, Michel; (US).
ZARATE, Carlos A.; (US).
TORJMAN, Marc C.; (US).
GOLDBERG, Michael E.; (US).
TANGA, Mary J.; (US)
Agent: MAXWELL, Leslie-Anne; Cantor Colburn LLP 20 Church Street, 22nd Floor Hartford, Connecticut 06103 (US)
Priority Data:
61/547,336 14.10.2011 US
Title (EN) THE USE OF (2R, 6R)-HYDROXYNORKETAMINE, (S)-DEHYDRONORKETAMINE AND OTHER STEREOISOMERIC DEHYDRO AND HYDROXYLATED METABOLITES OF (R,S)- KETAMINE IN THE TREATMENT OF DEPRESSION AND NEUROPATHIC PAIN
(FR) UTILISATION DE (2R, 6R)-HYDROXYNORKÉTAMINE, (S)-DÉSHYDRONORKÉTAMINE ET AUTRES MÉTABOLITES DÉSHYDRO ET HYDROXYLÉS STÉRÉO-ISOMÈRES DE (R,S)-KÉTAMINE DANS LE TRAITEMENT DE LA DÉPRESSION ET DE LA DOULEUR NEUROPATHIQUE
Abstract: front page image
(EN)The disclosure provides pharmaceutical preparations containing (2R,6R)-hydroxynorketamine, or (R)- or (S)-dehydronorketamine, or other stereoisomeric dehydro or hydroxylated ketamine metabolite. (2R,6R)-hydroxynorketamine The disclosure also provides novel ketamine metabolite prodrugs. The disclosure provides methods of treating, bipolar depression, major depressive disorder, neuropathic and chronic pain, including complex regional pain disorder (CRPS) by administering a purified ketamine metabolite or a ketamine metabolite prodrug directly to patients in need of such treatment.
(FR)L'invention concerne des préparations pharmaceutiques contenant de la (2R, 6R)-hydroxynorkétamine, ou de la (R)- ou (S)-déshydronorkétamine ou autre métabolite de kétamine déshydro ou hydroxylé stéréo-isomère. L'invention concerne également de nouveaux promédicaments à base de métabolite de kétamine. L'invention concerne aussi des procédés de traitement de la dépression bipolaire, du trouble dépressif majeur, de la douleur neuropathique et chronique, comprenant le syndrome douloureux régional complexe (SRDC), par administration d'un métabolite de kétamine purifié ou d'un promédicament de métabolite de kétamine directement à des patients ayant besoin d'un tel traitement.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)