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Machine translation
1. (WO2013056221) COMPOSITIONS AND METHODS FOR MODULATING THROMBIN GENERATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/056221    International Application No.:    PCT/US2012/060232
Publication Date: 18.04.2013 International Filing Date: 15.10.2012
IPC:
A61K 38/36 (2006.01)
Applicants: THE CHILDREN'S HOSPITAL OF PHILADELPHIA [US/US]; 34th Street & Civic Center Boulevard Philadelphia, PA 19104 (US)
Inventors: CAMIRE, Rodney, M.; (US).
BUNCE, Matthew, W.; (US).
BOS, Mettine, H.A.; (NL)
Agent: NETTER, Robert, C.; Dann, Dorfman, Herrell & Skillman 1601 Market Street Suite 2400 Philadelphia, PA 19103-2307 (US)
Priority Data:
61/546,752 13.10.2011 US
Title (EN) COMPOSITIONS AND METHODS FOR MODULATING THROMBIN GENERATION
(FR) COMPOSITIONS ET PROCÉDÉS POUR LA MODULATION DE LA GÉNÉRATION DE THROMBINE
Abstract: front page image
(EN)In accordance with the instant invention, Factor V peptides for the modulation of thrombin generation are provided. In a particular embodiment, the peptide has at least 80% homology with SEQ ID NO: 1, 2, 3 or 4. Nucleic acid molecules encoding the peptides are also encompassed by the instant invention. Compositions comprising at least one peptide and/or nucleic acid of the instant invention and at least one pharmaceutically acceptable earner are also provided. The compositions may further comprise at least one other anti-thrombosis compound.
(FR)L'invention concerne des peptides du facteur V pour la modulation de la génération de la thrombine. Dans un mode de réalisation particulier, la peptide a au moins 80% d'homologie avec SEQ ID NO : 1, 2, 3 ou 4. L'invention concerne aussi des molécules d'acide nucléique codant pour les peptides. L'invention concerne également des compositions comprenant au moins un peptide et/ou un acide nucléique de la présente invention et au moins un support pharmaceutiquement acceptable. Les compositions peuvent encore comprendre au moins un autre composé anti-thrombose.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)