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1. (WO2013056178) NOVEL ESTROGEN RECEPTOR MUTATIONS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/056178    International Application No.:    PCT/US2012/060133
Publication Date: 18.04.2013 International Filing Date: 12.10.2012
IPC:
C12Q 1/68 (2006.01), G01N 33/53 (2006.01)
Applicants: FOUNDATION MEDICINE, INC. [US/US]; One Kendall Square, Suite B6501 Cambridge, MA 02139 (US)
Inventors: YELENSKY, Roman; (US).
STEPHENS, Philip, James; (US).
CRONIN, Maureen; (US).
PALMER, Gary; (US).
LIPSON, Doron; (US).
MILLER, Vincent, A.; .
ROSS, Jeffrey, S.; (US).
FRAMPTON, Garrett, Michael; (US)
Agent: COLLAZO, Diana, M.; Lando & Anastasi LLP Riverfront Office Park One Main Street, Suite 1100 Cambridge, MA 02142 (US)
Priority Data:
61/547,471 14.10.2011 US
61/615,821 26.03.2012 US
Title (EN) NOVEL ESTROGEN RECEPTOR MUTATIONS AND USES THEREOF
(FR) NOUVELLES MUTATIONS DE RÉCEPTEUR DES ESTROGÈNES ET LEURS UTILISATIONS
Abstract: front page image
(EN)Methods of identifying breast cancer patients resistant to SERM therapy by detecting mutant estrogen receptor are disclosed. The method comprises identifying specific estrogen receptor mutations with a reaction mixture comprising a detection reagent and a target nucleic acid derived from a breast cancer that is estrogen receptor positive, malignant and resistant to treatment with a first or second line SERM therapy.
(FR)L'invention concerne de nouvelles molécules mutantes d'ESR1 et leurs utilisations.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)