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Machine translation
1. (WO2013056122) ENGINEERED OUTER DOMAIN (EOD) OF HIV GP120 AND MUTANTS THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/056122    International Application No.:    PCT/US2012/060062
Publication Date: 18.04.2013 International Filing Date: 12.10.2012
IPC:
A61K 38/00 (2006.01), A61K 39/21 (2006.01), G01N 33/564 (2006.01)
Applicants: UNIVERSITY OF WASHINGTON [US/US]; Through Its Center For Commercialization 4311 11th Avenue NE, Suite 500 Seattle, WA 98105 (US).
THE SCRIPPS RESEARCH INSTITUTE [US/US]; 10550 North Torrey Pines Road La Jolla, CA 92037 (US).
INTERNATIONAL AIDS VACCINE INITIATIVE [US/US]; 125 Broad Street 9th Floor New York, NY 10004 (US).
HUANG, Po-Ssu [US/US]; (US).
JARDINE, Joseph, Graham [US/US]; (US).
MENIS, Sergey, V. [US/US]; (US).
SCHIEF, William, Ray [US/US]; (US)
Inventors: HUANG, Po-Ssu; (US).
JARDINE, Joseph, Graham; (US).
MENIS, Sergey, V.; (US).
SCHIEF, William, Ray; (US)
Agent: KOWALSKI, Thomas, J.; Vedder Price P.C. 1633 Broadway New York, NY 10019 (US)
Priority Data:
61/699,217 10.09.2012 US
61/546,465 12.10.2011 US
Title (EN) ENGINEERED OUTER DOMAIN (EOD) OF HIV GP120 AND MUTANTS THEREOF
(FR) DOMAINE EXTERNE GÉNÉTIQUEMENT MODIFIÉ (EOD) DE GP120 DU VIH ET MUTANTS ASSOCIÉS
Abstract: front page image
(EN)The invention relates to an engineered outer domain (eOD) of HIV gp120 and mutants thereof and methods of making and using the same. The mutant eODs may be advantageous for the elicitation of CD4-binding site (CD4bs)-directed broadly-neutralizing antibodies (bnAbs) and/or improve binding to mature VRCOl and/or improve binding to germline VRCOl and the germlines of other VH1-2 derived broadly-neutralizing antibodies. The mutant eODs may also include glycan-masking mutations on eOD. The present invention also includes fusions of eOD to various protein multimers to enhance immunogenicity as well as the design of cocktails of different eODs that represent the full diversity of HIV sequences within the VRCOl epitope and surroundings.
(FR)L'invention concerne un domaine externe génétiquement modifié (eOD) de gp120 du VIH et les mutants associés, et des procédés de fabrication et d'utilisation de ceux-ci. Les eOD mutants peuvent être avantageux pour le déclenchement d'anticorps de neutralisation à large spectre dirigés contre un site de liaison à CD4 (CD4bs) (bnAb) et/ou améliorent la liaison à VRCOl mature et/ou améliorent la liaison à VRCOl de la lignée germinale et aux lignées germinales d'autres anticorps de neutralisation à large spectre issus de VH1-2. Les eOD mutants peuvent également comprendre des mutations masquant un glycane sur eOD. La présente invention concerne également des fusions d'eOD à divers multimères protéiques pour améliorer l'immunogénéicité ainsi que la conception de cocktails d'eOD différents qui représentent la pleine diversité entière de séquences du VIH à l'intérieur de l'épitope VRCOl et de son voisinage.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)