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1. (WO2013056034) SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS AS FACTOR XIA INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/056034    International Application No.:    PCT/US2012/059932
Publication Date: 18.04.2013 International Filing Date: 12.10.2012
IPC:
C07D 217/26 (2006.01), C07D 401/10 (2006.01), C07D 401/12 (2006.01), C07D 401/14 (2006.01), C07D 405/14 (2006.01), A61K 31/4725 (2006.01), A61P 7/02 (2006.01)
Applicants: BRISTOL-MYERS SQUIBB COMPANY [US/US]; P.O. Box 4000 Route 206 and ProvinceLine Road Princeton, New Jersey 08543-4000 (US)
Inventors: ORWAT, Michael J.; (US).
PINTO, Donald J.P.; (US).
SMITH II, Leon M.; (US).
SRIVASTAVA, Shefali; (IN)
Agent: LIU, Hong; Bristol-Myers Squibb Company P.O. Box 4000 Princeton, New Jersey 08543-4000 (US)
Priority Data:
61/547,301 14.10.2011 US
Title (EN) SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS AS FACTOR XIA INHIBITORS
(FR) COMPOSÉS DE TÉTRAHYDROISOQUINOLÉINE SUBSTITUÉS EN TANT QU'INHIBITEURS DU FACTEUR XIA
Abstract: front page image
(EN)The present invention provides compounds of Formula (I) or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of factor XIa and/or plasma kallikrein which may be used as medicaments.
(FR)La présente invention concerne des composés de Formule (I) ou des stéréoisomères, des sels pharmaceutiquement acceptables de ceux-ci, dans lesquels toutes les variables sont comme définies ici. Ces composés sont des inhibiteurs du facteur XIa et/ou de la kallicréine plasmatique qui peuvent être utilisés en tant que médicaments.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)