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1. (WO2013056015) ISOINDOLINONE AND PYRROLOPYRIDINONE DERIVATIVES AS AKT INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/056015    International Application No.:    PCT/US2012/059905
Publication Date: 18.04.2013 International Filing Date: 12.10.2012
IPC:
C07D 401/14 (2006.01), C07D 403/04 (2006.01), C07D 403/14 (2006.01), C07D 409/14 (2006.01), C07D 417/14 (2006.01), C07D 471/02 (2006.01), C07D 487/02 (2006.01), A61K 31/4155 (2006.01), A61P 35/00 (2006.01)
Applicants: INCYTE CORPORATION [US/US]; Experimental Station Route 141 & Henry Clay Road Building E336/207 Wilmington, Delaware 19880 (US)
Inventors: HUANG, Taisheng; (US).
FENG, Hao; (US).
KONG, Lingquan; (US).
WANG, Anlai; (US).
YE, Hai Fen; (US).
XUE, Chu-Biao; (US)
Agent: GODDARD, Christine A.; Fish & Richardson P.C. P. O. Box 1022 Minneapolis, MN 55440-1022 (US)
Priority Data:
61/547,293 14.10.2011 US
Title (EN) ISOINDOLINONE AND PYRROLOPYRIDINONE DERIVATIVES AS AKT INHIBITORS
(FR) DÉRIVÉS D'ISOINDOLINONE ET DE PYRROLOPYRIDINONE EN TANT QU'INHIBITEURS D'AKT
Abstract: front page image
(EN)The present invention provides isoindolinone and pyrrolopyridinone derivatives, as well as their compositions and methods of use, that inhibit the activity of the serine/threonine kinase, Akt, and are useful in the treatment of diseases related to the activity of Akt including, for example, cancer and other diseases.
(FR)La présente invention concerne des dérivés d'isoindolinone et de pyrrolopyridinone ainsi que leurs compositions et leurs procédés d'utilisation, qui inhibent l'activité de la sérine/thréonine kinase, l'Akt, et sont utiles dans le traitement de maladies liées à l'activité de l'Akt comprenant, par exemple, le cancer et d'autres maladies.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)