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1. (WO2013055958) IMPROVED ASSEMBLY OF BISPECIFIC ANTIBODIES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/055958    International Application No.:    PCT/US2012/059810
Publication Date: 18.04.2013 International Filing Date: 11.10.2012
IPC:
C07K 16/46 (2006.01)
Applicants: GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, California 94080 (US) (AE, AG, AM, AO, AU, AZ, BB, BF, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CI, CL, CM, CO, CR, CU, DM, DO, DZ, EC, EG, GA, GD, GE, GH, GM, GN, GQ, GT, GW, HN, ID, IL, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LY, MA, MD, ME, MG, ML, MN, MR, MW, MX, MY, MZ, NA, NE, NG, NI, NZ, OM, PA, PE, PG, PH, QA, RU, RW, SC, SD, SG, SL, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW only).
F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel (CH) (AL, AT, BA, BE, BG, CH, CN, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IN, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR only)
Inventors: GIESE, Glen; (US).
PERSSON, Josefine; (US).
WILLIAMS, Ambrose; (US).
LIM, Amy; (US).
SCHEER, Justin; (US)
Agent: CHANG, Y. Elaine; Genentech, Inc. 1 DNA Way, MS-49 South San Francisco, California 94080 (US)
Priority Data:
61/545,863 11.10.2011 US
61/546,503 12.10.2011 US
61/560,704 16.11.2011 US
61/676,837 27.07.2012 US
Title (EN) IMPROVED ASSEMBLY OF BISPECIFIC ANTIBODIES
(FR) ASSEMBLAGE AMÉLIORÉ D'ANTICORPS BISPÉCIFIQUES
Abstract: front page image
(EN)Described herein are methods for the efficient production of a heteromultimeric protein, such as a bispecific antibody. Heteromultimeric proteins may be capable of specifically binding to more than one target molecule or different epitopes on a single target molecule. The methods modulate parameters to improve assembly of the heteromultimeric proteins at higher yield and efficiency than otherwise possible. Also described are compositions comprising a hinge-containing polypeptide, such as a half-antibody.
(FR)La présente invention concerne des procédés pour la production efficace d'une protéine hétéromultimérique telle qu'un anticorps bispécifique. Des protéines hétéromultimériques peuvent se lier spécifiquement à plusieurs molécules cibles ou à différents épitopes sur une seule molécule cible. Les procédés modulent des paramètres pour améliorer l'assemblage des protéines hétéromultimériques avec un rendement supérieur et une plus grande efficacité que ce qui est autrement possible. L'invention concerne également des compositions comprenant un polypeptide contenant une charnière, tel qu'un demi-anticorps.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)