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1. (WO2013055913) PGAM1 INHIBITORS AND METHODS RELATED THERETO
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/055913    International Application No.:    PCT/US2012/059740
Publication Date: 18.04.2013 International Filing Date: 11.10.2012
IPC:
C07C 311/12 (2006.01), C07C 311/16 (2006.01), A61K 31/18 (2006.01), A61P 35/00 (2006.01)
Applicants: EMORY UNIVERSITY [US/US]; Office of Technology Transfer 1599 Clifton Road NE, 4th Floor Atlanta, Georgia 30322 (US)
Inventors: CHEN, Jing; (US).
HITOSUGI, Taro; (US).
KANG, Sumin; (US)
Agent: MASON, James C.; Emory University Office of Technology Transfer 1599 Clifton Road NE, 4th Floor Atlanta, Georgia 30322 (US)
Priority Data:
61/547,278 14.10.2011 US
Title (EN) PGAM1 INHIBITORS AND METHODS RELATED THERETO
(FR) INHIBITEURS DE PGAM1 ET PROCÉDÉS ASSOCIÉS
Abstract: front page image
(EN)In certain embodiments, the disclosure relates to methods of treating or preventing a PGAM1 mediated condition such as cancer or tumor growth comprising administering an effective amount of PGAM1 inhibitor, for example, an anthracene-9,10-dione derivative to a subject in need thereof. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer, head and neck cancer, and leukemia, comprising administering a therapeutically effective amount of a pharmaceutical composition comprising a compound disclosed herein or pharmaceutically acceptable salt to a subject in need thereof.
(FR)L'invention concerne, selon certains modes de réalisation, des procédés de traitement ou de prévention d'un trouble médié par PGAM1, tel qu'un cancer ou le développement d'une tumeur, comprenant l'administration d'une quantité efficace d'un inhibiteur de PGAM1, par exemple d'un dérivé d'anthracène-9,10-dione, à un sujet en ayant besoin. Selon certains modes de réalisation, l'invention concerne des procédés de traitement ou de prévention d'un cancer, tel que le cancer du poumon, le cancer de la tête et du cou, et la leucémie, comprenant l'administration d'une quantité thérapeutiquement efficace d'une composition pharmaceutique comprenant un composé décrit dans le présent document ou un sel pharmaceutiquement acceptable à un sujet en ayant besoin.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)