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1. (WO2013055888) RECOMBINANT HUMAN NAGLU PROTEIN AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/055888    International Application No.:    PCT/US2012/059708
Publication Date: 18.04.2013 International Filing Date: 11.10.2012
IPC:
C12N 9/26 (2006.01), C12N 5/07 (2010.01), A61K 38/47 (2006.01)
Applicants: SYNAGEVA BIOPHARMA CORP. [US/US]; 128 Spring Street Suite 520 Lexington, MA 02421 (US)
Inventors: QUINN, Anthony; (US).
LEAVITT, Markley, C.; (US).
ZHINAN, Xia; (US).
RUTKOWSKI, Joseph, Victor; (US)
Agent: Robert H. Underwood; McDermott Will & Emery LLP 28 State Street Boston, MA 02109 (US)
Priority Data:
61/546,248 12.10.2011 US
Title (EN) RECOMBINANT HUMAN NAGLU PROTEIN AND USES THEREOF
(FR) PROTÉINE NAGLU HUMAINE RECOMBINANTE ET SES UTILISATIONS
Abstract: front page image
(EN)The present invention provides compositions comprising an isolated mixture of recombinant human NaGlu proteins in which a substantial amount of the NaGlu proteins in the mixture has increased levels of phosphorylated mannose that confer the proteins to be efficiently internalized into human cells. The present invention also provides methods of producing such mixture of NaGlu proteins, vectors used in transgenesis and expression, host cells harboring such vectors, and methods of isolating and purifying the mixture of NaGlu proteins. The invention further provides methods of treating NaGlu associated diseases.
(FR)La présente invention concerne des compositions comprenant un mélange isolé de protéines NaGlu humaines recombinantes dans lequel une quantité substantielle des protéines NaGlu dans le mélange présente des taux accrus de mannose phosphorylé qui confère aux protéines la capacité à être internalisées efficacement dans des cellules humaines. La présente invention concerne également des procédés de production de tel mélange de protéines NaGlu, des vecteurs utilisés dans la transgenèse et l'expression, des cellules hôtes portant de tels vecteurs, et des procédés d'isolement et de purification du mélange de protéines NaGlu. L'invention concerne en outre des méthodes de traitement de maladies associées à NaGlu.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)