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1. (WO2013054770) ANEMIA OF CANCER IMPROVING / PROPHYLACTIC AGENT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/054770    International Application No.:    PCT/JP2012/076020
Publication Date: 18.04.2013 International Filing Date: 05.10.2012
IPC:
A61K 31/197 (2006.01), A61K 31/28 (2006.01), A61K 33/06 (2006.01), A61K 33/24 (2006.01), A61K 33/26 (2006.01), A61K 33/30 (2006.01), A61K 33/34 (2006.01), A61P 7/06 (2006.01), A61P 43/00 (2006.01)
Applicants: SBI PHARMACEUTICALS CO., LTD. [JP/JP]; 6-1, Roppongi 1-chome, Minato-ku, Tokyo 1066020 (JP)
Inventors: TANAKA, Tohru; (JP).
NAKAJIMA, Motowo; (JP).
ABE, Fuminori; (JP).
KAWATA, Satofumi; (JP).
TAKAHASHI, Kiwamu; (JP)
Agent: NANJO, Masahiro; TOKYO ACTi International Patent Office, 9-7-2-1416, Akasaka, Minato-ku, Tokyo 1070052 (JP)
Priority Data:
2011-225383 12.10.2011 JP
2012-081346 30.03.2012 JP
Title (EN) ANEMIA OF CANCER IMPROVING / PROPHYLACTIC AGENT
(FR) AGENT D'AMÉLIORATION/PROPHYLACTIQUE DE L'ANÉMIE DU CANCER
(JA) がん性貧血改善・予防剤
Abstract: front page image
(EN)[Problem] To provide an anemia of cancer improving and/or prophylactic agent which is useful in improving and preventing anemia of cancer and which can improve the QOL of patients of anemia of cancer without promoting the progress of the cancer. [Solution] An anemia of cancer improving and/or prophylactic agent is prepared which contains 5-aminolevulinic acid (ALA), a derivative thereof, or a salt of the same. Preferably, the ALA substance contains a metal-containing compound such as ferrous sodium citrate. As optimal examples of the aforementioned ALA substances may be given ALA, various esters (such as methyl ester, ethyl ester, propyl ester, butyl ester, and pentyl ester) of ALA, and hydrochlorides, phosphates and sulfates of these.
(FR)L'objectif de l'invention est de fournir un agent d'amélioration et/ou prophylactique de l'anémie du cancer qui est utile dans l'amélioration et la prévention de l'anémie du cancer et qui peut améliorer le QOL de patients présentant une anémie de cancer sans promouvoir la progression du cancer. L'invention concerne un agent d'amélioration et/ou prophylactique de l'anémie du cancer qui est préparé, lequel contient l'acide 5-aminolévulinique (ALA), un dérivé de celui-ci, ou un sel de celui-ci. De préférence, la substance ALA contient un composé contenant un métal, tel qu'un citrate de sodium ferreux. Des exemples optimaux des substances ALA mentionnées ci-dessus peuvent être l'ALA donné, divers esters (tels qu'un méthylester, un éthylester, un propylester, un butylester et un pentylester) d'ALA, et des chlorhydrates, phosphates et sulfates de ceux-ci.
(JA)【課題】がんの進行を進めることなく、がん性貧血患者のQOLを向上させることができる、がん性貧血の改善や予防に有用な貧血改善及び/又は予防剤を提供する。 【解決手段】5-アミノレブリン酸(ALA)若しくはその誘導体又はその塩を含有するがん性貧血の改善及び/又は予防剤を調製する。これらALA類にクエン酸第一鉄ナトリウム等の金属含有化合物を含有させることが好ましい。上記ALA類としては、ALA、及び同メチルエステル、エチルエステル、プロピルエステル、ブチルエステル、ペンチルエステル等の各種エステル類、並びに、これらの塩酸塩、リン酸塩、硫酸塩等を好適に例示することができる。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)