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Machine translation
1. (WO2013054346) A PROCESS FOR THE PREPARATION OF N-PROPRAGYL 1-AMINO INDANE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/054346    International Application No.:    PCT/IN2012/000500
Publication Date: 18.04.2013 International Filing Date: 16.07.2012
IPC:
C07C 209/84 (2006.01), C07C 211/42 (2006.01)
Applicants: ALKEM LABORATORIES LIMITED [IN/IN]; Ddevashish, Alkem House Senapati Bapat Marg Lower parel Mumbai 400 013 Maharashtra (IN) (For All Designated States Except US).
SANTOSH, Vitthal Pune [IN/IN]; (IN) (For US Only).
PRASHANT, Pandurang Pawar [IN/IN]; (IN) (For US Only).
DHARMESH, Kumar Arvindbhai Patel [IN/IN]; (IN) (For US Only)
Inventors: SANTOSH, Vitthal Pune; (IN).
PRASHANT, Pandurang Pawar; (IN).
DHARMESH, Kumar Arvindbhai Patel; (IN)
Agent: ADVOCATE SANJAY KHER; 176-A, Vaishali (rear Bungalow), Bhalchandra Road Hindu Colony, Dadar (east) Mumbai 400 014 (IN)
Priority Data:
2036/MUM/2011 15.07.2011 IN
Title (EN) A PROCESS FOR THE PREPARATION OF N-PROPRAGYL 1-AMINO INDANE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF
(FR) PROCÉDÉ DE PRÉPARATION DE N-PROPRAGYL 1-AMINO INDANE ET DE SELS PHARMACEUTIQUEMENT ACCEPTABLES CORRESPONDANTS
Abstract: front page image
(EN)The present invention is directed to a process for the preparation of N-propargyl 1 -amino indane and pharmaceutically acceptable salts thereof by a process comprising: a) providing a reaction mixture comprising N-propargyl-1 -amino indane and/or a salt thereof, b) purifying N-propargyl-1 -amino indane free base exclusively by selective pH adjustment and selective extraction, c) optionally isolating N-propargyl- 1 -amino indane free base or converting insitu to its pharmaceutically acceptable salt thereof.
(FR)La présente invention concerne un procédé pour la préparation de N-propargyl 1-amino indane et de sels pharmaceutiquement acceptables correspondants, au moyen d'un procédé consistant: a) à obtenir un mélange réactionnel comprenant du N-propargyl-1-amino indane et/ou un sel correspondant, b) à purifier une base libre de N-propargyl-1-amino indane uniquement par ajustement de pH sélectif et extraction sélective, c) éventuellement à isoler la base libre de N-propargyl-1-amino indane ou à la convertir in situ en son sel pharmaceutiquement acceptable.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)