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1. (WO2013054131) ASYMMETRIC SYNTHESIS OF ORGANIC COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/054131    International Application No.:    PCT/GB2012/052537
Publication Date: 18.04.2013 International Filing Date: 12.10.2012
IPC:
C07B 53/00 (2006.01), C07C 45/69 (2006.01), C07C 49/403 (2006.01), C07C 49/413 (2006.01), C07C 49/463 (2006.01)
Applicants: ISIS INNOVATION LIMITED [GB/GB]; Ewert House Ewert Place Summertown, Summertown Oxford Oxfordshire OX2 7SG (GB) (For All Designated States Except US).
FLETCHER, Stephen P. [CA/GB]; (GB) (US only).
MAKSYMOWICZ, Rebecca M. [GB/GB]; (GB) (US only).
ROTH, Philippe M.C. [CH/GB]; (GB) (US only)
Inventors: FLETCHER, Stephen P.; (GB).
MAKSYMOWICZ, Rebecca M.; (GB).
ROTH, Philippe M.C.; (GB)
Agent: SIMPSON, Tobias; Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG (GB)
Priority Data:
1117809.2 14.10.2011 GB
1216666.6 18.09.2012 GB
Title (EN) ASYMMETRIC SYNTHESIS OF ORGANIC COMPOUNDS
(FR) SYNTHÈSE ASYMÉTRIQUE DE COMPOSÉS ORGANIQUES
Abstract: front page image
(EN)The present invention provides processes for the production of chiral compounds in a stereoisomeric excess. The present processes involve reacting a hydrometallated alkene compound with a compound comprising a conjugated -bond system under conditions such that the compounds undergo an asymmetric 1,4- or 1,6-conjugate addition reaction, generating a chiral compound in a stereoisomeric excess. The reaction is performed in the presence of a metal catalyst, which catalyst preferably comprises a non-racemic chiral ligand.
(FR)Cette invention concerne des procédés de production de composés chiraux en excès stéréoisomérique, les présents procédés comprenant la réaction d'un composé d'alcène hydrométallaté avec un composé comprenant un système de liaisons conjuguées dans des conditions telles que les composés subissent une réaction d'addition asymétrique de 1,4- ou 1,6-conjugué, générant un composé chiral en excès stéréoisomérique. La réaction est mise en œuvre en présence d'un catalyseur métallique, ledit catalyseur comprenant de préférence un ligand chiral non racémique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)