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1. (WO2013054108) MONO-FLUORO BETA-SECRETASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/054108    International Application No.:    PCT/GB2012/052510
Publication Date: 18.04.2013 International Filing Date: 10.10.2012
IPC:
C07D 207/34 (2006.01), C07D 401/10 (2006.01), C07D 403/10 (2006.01), C07D 491/107 (2006.01), A61K 31/506 (2006.01), A61K 31/4439 (2006.01), A61P 25/00 (2006.01), A61P 25/28 (2006.01)
Applicants: ASTRAZENECA AB [SE/SE]; SE-151 85 Södertälje (SE) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW only).
ASTRAZENECA UK LIMITED [GB/GB]; 2 Kingdom Street London Greater London W2 6BD (GB) (MG only)
Inventors: MINIDIS, Anna; (SE).
RAHM, Fredrik; (GB).
VIKLUND, Jenny; (GB)
Priority Data:
61/545,334 10.10.2011 US
Title (EN) MONO-FLUORO BETA-SECRETASE INHIBITORS
(FR) INHIBITEURS DE MONO FLUORO-BÊTA-SECRETASE
Abstract: front page image
(EN)Beta-secretase inhibitors, of formula (I) as described in the specification, pharmaceutical compositions comprising them and therapeutic methods using them for the treatment and/or prevention of Αβ-related pathologies such as Down's syndrome, β-amyloid angiopathy such as but not limited to cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to MCI ("mild cognitive impairment"), Alzheimer's Disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration.
(FR)L'invention concerne des inhibiteurs de bêta-sécrétase, de formule (I) tel qu'énoncé dans la description, des compositions pharmaceutiques les comprenant et des méthodes thérapeutiques les utilisant pour le traitement et/ou la prévention de pathologies liées à Αβ telles que le syndrome de Down, l'angiopathie amyloïde β, dont entre autres l'angiopathie amyloïde cérébrale ou l'hémorragie cérébrale héréditaire, les troubles associés à la déficience cognitive, dont entre autres la DCL ("déficience cognitive légère"), la maladie d'Alzheimer, la perte de mémoire, les symptômes des troubles déficitaires de l'attention associés à la maladie d'Alzheimer, la neurodégénérescence associée à des maladies telles que la maladie d'Alzheimer ou la démence dont la démence d'origine vasculaire et dégénérative mixte, la démence présénile, la démence sénile et la démence associée à la maladie de Parkinson, la paralysie supranucléaire progressive ou la dégénérescence basale corticale.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)