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1. (WO2013053833) 2 - CARBOXAMIDE CYCLOAMINO UREA DERIVATIVES IN COMBINATION WITH HSP90 INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/053833    International Application No.:    PCT/EP2012/070171
Publication Date: 18.04.2013 International Filing Date: 11.10.2012
IPC:
A61K 31/428 (2006.01), A61K 31/4439 (2006.01), A61K 31/497 (2006.01), A61K 31/506 (2006.01), A61K 45/06 (2006.01), A61K 35/00 (2006.01)
Applicants: NOVARTIS AG [CH/CH]; Lichtstrasse 35 CH-4056 Basel (CH) (For All Designated States Except US).
HUANG, Xizhong [US/US]; (US) (US only).
QUADT, Cornelia [DE/CH]; (CH) (US only).
WANG, Hui-Qin [US/US]; (US) (US only).
FRITSCH, Christine [FR/CH]; (CH) (US only).
SCHNELL, Christian René [FR/CH]; (CH) (US only)
Inventors: HUANG, Xizhong; (US).
QUADT, Cornelia; (CH).
WANG, Hui-Qin; (US).
FRITSCH, Christine; (CH).
SCHNELL, Christian René; (CH)
Agent: GRUBER, Markus; Novartis Pharma AG Patent Department CH-4002 Basel (CH)
Priority Data:
61/547,308 14.10.2011 US
Title (EN) 2 - CARBOXAMIDE CYCLOAMINO UREA DERIVATIVES IN COMBINATION WITH HSP90 INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES
(FR) DÉRIVÉS DE 2-CARBOXAMIDE CYCLOAMINO URÉE EN COMBINAISON AVEC DES INHIBITEURS D'HSP90 POUR LE TRAITEMENT DE MALADIES PROLIFÉRATIVES
Abstract: front page image
(EN)The present invention relates to a pharmaceutical combination comprising a 2-carboxamide cycloamino urea derivative compound of formula (I) and inhibitors of Heat Shock Protein 90, and the uses of such combinations in the treatment of proliferative diseases, more specifically PI3K dependent diseases, more specifically PI3K-alpha dependent diseases.
(FR)La présente invention concerne une combinaison pharmaceutique comprenant un composé dérivé de 2-carboxamide cycloamino urée de formule (I) et des inhibiteurs de la Protéine 90 de Choc Thermique, et les utilisations de telles combinaisons dans le traitement de maladies prolifératives, plus spécialement de maladie dépendantes de PI3K, plus particulièrement de maladies dépendantes de PI3K-alpha.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)