WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2013053775) COMBINATION MEDICAMENT COMPRISING IL-12 AND AN AGENT FOR BLOCKADE OF T-CELL INHIBITORY MOLECULES FOR TUMOUR THERAPY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/053775    International Application No.:    PCT/EP2012/070088
Publication Date: 18.04.2013 International Filing Date: 10.10.2012
IPC:
A61K 38/20 (2006.01), A61K 39/395 (2006.01), A61K 45/06 (2006.01), A61P 35/00 (2006.01)
Applicants: UNIVERSITÄT ZÜRICH PROREKTORAT MNW [CH/CH]; Rämistrasse 71 CH-8006 Zürich (CH) (For All Designated States Except US).
BECHER, Burkhard [CH/CH]; (CH) (US only).
VOM BERG, Johannes [DE/CH]; (CH) (US only)
Inventors: BECHER, Burkhard; (CH).
VOM BERG, Johannes; (CH)
Agent: JUNGHANS, Claas; Schulz Junghans Patentanwälte Chausseestrasse 5 10115 Berlin (DE)
Priority Data:
11184644.0 11.10.2011 EP
11188625.5 10.11.2011 EP
61/573,200 14.11.2011 US
12185108.3 19.09.2012 EP
Title (EN) COMBINATION MEDICAMENT COMPRISING IL-12 AND AN AGENT FOR BLOCKADE OF T-CELL INHIBITORY MOLECULES FOR TUMOUR THERAPY
(FR) COMBINAISON MÉDICAMENTEUSE COMPRENANT DE L'IL-12 ET UN AGENT DE BLOCAGE DE MOLÉCULES INHIBITRICES DES LYMPHOCYTES T POUR UNE THÉRAPIE ANTI-TUMORALE
Abstract: front page image
(EN)The invention relates to a combination medicament for treatment of malignant neoplastic disease. The combination medicament comprises an IL-12 polypeptide having a biological activity of IL-12 or a nucleic acid expression vector comprising a sequence encoding such IL-12 polypeptide, and a non-agonist CTLA-4 ligand or non-agonist PD-1 ligand, particularly an anti-CTLA-4 or anti-PD-1 immunoglobulin G.
(FR)L'invention concerne une combinaison médicamenteuse pour le traitement d'une maladie néoplasique maligne. La combinaison médicamenteuse comprend un polypeptide IL-12 ayant une activité biologique de l'IL-12 ou un vecteur d'expression d'acide nucléique comprenant une séquence codant pour un tel polypeptide IL-12, et un ligand non agoniste de CTLA-4 ou un ligand non agoniste de PD-1, en particulier une immunoglobine G anti-CTLA-4 ou anti-PD-1.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)