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1. (WO2013053739) PROCESS FOR PREPARING FACTOR XA INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/053739    International Application No.:    PCT/EP2012/070034
Publication Date: 18.04.2013 International Filing Date: 10.10.2012
IPC:
C07D 413/10 (2006.01), C07D 413/14 (2006.01), A61K 31/5377 (2006.01), A61P 7/02 (2006.01)
Applicants: LABORATORIOS LESVI, S. L. [ES/ES]; Avda. Barcelona, 69 E-08970 Sant Joan Despi (Barcelona) (ES)
Inventors: VISHNU NEWADKAR, Ravindranath; (IN).
CHANGDEO GAIKWAD, Avinash; (IN).
MADHUKAR HARAD, Ajay; (IN).
DALMASES BARJOAN, Pere; (ES)
Agent: PONS ARIÑO, Ángel; Glorieta de Rubén Darío, 4 E-28010 Madrid (ES)
Priority Data:
11184532.7 10.10.2011 EP
61/545,519 10.10.2011 US
Title (EN) PROCESS FOR PREPARING FACTOR XA INHIBITORS
(FR) PROCÉDÉ DE PRÉPARATION D'INHIBITEURS DU FACTEUR XA
Abstract: front page image
(EN)The present invention relates to a process for the manufacturing of a rivaroxaban or a pharmaceutically acceptable salt thereof, wherein the process comprises obtaining an acid addition salt of a 4-{4-[(5S))-5-(aminomethyl)-2-oxo-1,3-oxozoladine-3- yl]phenyl}morpholin-3-one, and reacting the acid addition salt with the suitable reagents to obtain rivaroxaban or a salt thereof.
(FR)La présente invention concerne un procédé de production de rivaroxaban ou d'un sel pharmaceutiquement acceptable de celui-ci, le procédé consistant à obtenir un sel d'addition acide d'une 4-{4-[(5S))-5-(aminométhyl)-2-oxo-1,3-oxozoladine-3-yl]phényl}morpholin-3-one, et à faire réagir le sels d'addition acide avec les réactifs appropriés pour obtenir le rivaroxaban ou un sel de celui-ci.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)